(Q38110420)

29 August 2017

The mechanisms of Hedgehog signalling and its roles in development and disease (English)

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29 August 2017

James Briscoe

1

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author name string

Pascal P Thérond

series ordinal

2

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PubMed ID

23719536

29 August 2017

language of work or name

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30 May 2013

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Nature Reviews Molecular Cell Biology

29 August 2017

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29 August 2017

14

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29 August 2017

416-429

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29 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm3598

29 August 2017

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cites work

Mutations affecting segment number and polarity in Drosophila

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Hedgehog signaling in animal development: paradigms and principles

31 March 2020

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Sonic hedgehog mediates the polarizing activity of the ZPA

31 March 2020

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

31 March 2020

1 reference

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

31 March 2020

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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

31 March 2020

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Limbs: a model for pattern formation within the vertebrate body plan

31 March 2020

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

31 March 2020

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Gli proteins in development and disease

31 March 2020

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Tissue repair and stem cell renewal in carcinogenesis

31 March 2020

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Mechanisms and functions of Hedgehog signalling across the metazoa

31 March 2020

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Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution

31 March 2020

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Novel lipid modifications of secreted protein signals

31 March 2020

1 reference

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

31 March 2020

1 reference

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

31 March 2020

1 reference

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly.

31 March 2020

1 reference

Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.

31 March 2020

1 reference

A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain.

31 March 2020

1 reference

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

31 March 2020

1 reference

Identification of a palmitic acid-modified form of human Sonic hedgehog

31 March 2020

1 reference

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

31 March 2020

1 reference

Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

31 March 2020

1 reference

A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

31 March 2020

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Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

31 March 2020

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Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

31 March 2020

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Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand

31 March 2020

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The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins

31 March 2020

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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

31 March 2020

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Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

31 March 2020

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Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

31 March 2020

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Nanoscale organization of hedgehog is essential for long-range signaling

31 March 2020

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A freely diffusible form of Sonic hedgehog mediates long-range signalling

31 March 2020

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Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

31 March 2020

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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

31 March 2020

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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

31 March 2020

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Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand

31 March 2020

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Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

31 March 2020

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Sonic hedgehog shedding results in functional activation of the solubilized protein.

31 March 2020

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A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form.

31 March 2020

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Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids

31 March 2020

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Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

31 March 2020

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Cholesterol modification restricts the spread of Shh gradient in the limb bud.

31 March 2020

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The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

31 March 2020

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Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis

31 March 2020

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Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

31 March 2020

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Lipoprotein-heparan sulfate interactions in the Hh pathway.

31 March 2020

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Lipoprotein particles are required for Hedgehog and Wingless signalling

31 March 2020

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Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface.

31 March 2020

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The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog

31 March 2020

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Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog

31 March 2020

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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

31 March 2020

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Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process.

31 March 2020

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Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

31 March 2020

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DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.

31 March 2020

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Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord.

31 March 2020

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Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung

31 March 2020

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Dual roles for patched in sequestering and transducing Hedgehog

31 March 2020

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

31 March 2020

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Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila

31 March 2020

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Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs

31 March 2020

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Release and transportation of Hedgehog molecules

31 March 2020

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Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals

31 March 2020

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A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

31 March 2020

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The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

31 March 2020

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Interactions between Hedgehog proteins and their binding partners come into view

31 March 2020

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The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

31 March 2020

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Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

31 March 2020

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Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

31 March 2020

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Shaping morphogen gradients by proteoglycans

31 March 2020

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Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions

31 March 2020

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Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

31 March 2020

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Structure of a heparin-dependent complex of Hedgehog and Ihog

31 March 2020

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The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

31 March 2020

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Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

31 March 2020

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LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

31 March 2020

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The sterol-sensing domain: multiple families, a unique role?

31 March 2020

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Patched acts catalytically to suppress the activity of Smoothened

31 March 2020

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Hedgehog regulates smoothened activity by inducing a conformational switch

31 March 2020

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Structural basis of Wnt recognition by Frizzled

31 March 2020

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Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations

31 March 2020

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Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

31 March 2020

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Oxysterols are allosteric activators of the oncoprotein Smoothened

31 March 2020

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

31 March 2020

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

31 March 2020

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USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

31 March 2020

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Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

31 March 2020

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Patched regulates Smoothened trafficking using lipoprotein-derived lipids.

31 March 2020

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Patched, the receptor of Hedgehog, is a lipoprotein receptor

31 March 2020

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Role of lipid metabolism in smoothened derepression in hedgehog signaling

31 March 2020

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G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

31 March 2020

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Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

31 March 2020

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Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

31 March 2020

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Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

31 March 2020

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PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

31 March 2020

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Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

31 March 2020

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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

31 March 2020

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Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

31 March 2020

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Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

31 March 2020

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Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

31 March 2020

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Hedgehog signaling in development and cancer.

31 March 2020

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Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb.

31 March 2020

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Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

31 March 2020

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Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

31 March 2020

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A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome

31 March 2020

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Transcriptional activity of GLI1 is negatively regulated by protein kinase A.

31 March 2020

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

31 March 2020

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Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development

31 March 2020

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An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates

31 March 2020

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Hedgehog signaling: Costal-2 bridges the transduction gap.

31 March 2020

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Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

31 March 2020

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Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway

31 March 2020

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Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

31 March 2020

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Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling

31 March 2020

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Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses

31 March 2020

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The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

31 March 2020

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Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus

31 March 2020

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Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.

31 March 2020

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A quantification of pathway components supports a novel model of Hedgehog signal transduction

31 March 2020

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Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

31 March 2020

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Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

31 March 2020

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Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

31 March 2020

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A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

31 March 2020

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

31 March 2020

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Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

31 March 2020

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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

31 March 2020

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Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

31 March 2020

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Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

31 March 2020

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Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels

31 March 2020

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Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

31 March 2020

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SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors

31 March 2020

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The primary cilium: a signalling centre during vertebrate development

31 March 2020

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Patched1 regulates hedgehog signaling at the primary cilium

31 March 2020

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

31 March 2020

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

31 March 2020

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

31 March 2020

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

31 March 2020

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GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome

31 March 2020

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Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450

31 March 2020

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Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

31 March 2020

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Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain

31 March 2020

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Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

31 March 2020

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TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

31 March 2020

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The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

31 March 2020

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Dynamic association of proteasomal machinery with the centrosome

31 March 2020

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Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

31 March 2020

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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

31 March 2020

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Beta-arrestin-mediated localization of smoothened to the primary cilium

31 March 2020

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A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia

31 March 2020

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

31 March 2020

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

31 March 2020

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Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia

31 March 2020

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A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

31 March 2020

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Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

31 March 2020

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Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

31 March 2020

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Mechanisms of Hedgehog gradient formation and interpretation

31 March 2020

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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

31 March 2020

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

31 March 2020

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The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity

31 March 2020

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Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.

31 March 2020

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Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

31 March 2020

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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

31 March 2020

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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

31 March 2020

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Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

31 March 2020

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Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

31 March 2020

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Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity

31 March 2020

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Genome-wide association analysis identifies 20 loci that influence adult height

31 March 2020

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A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.

31 March 2020

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Role of the Drosophila patched gene in positional signalling

31 March 2020

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Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

31 March 2020

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A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

31 March 2020

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Hairy tale of signaling in hair follicle development and cycling

31 March 2020

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The crosstalk of mTOR/S6K1 and Hedgehog pathways

31 March 2020

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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

31 March 2020

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The Hedgehog's tale: developing strategies for targeting cancer

31 March 2020

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In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

31 March 2020

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

31 March 2020

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

31 March 2020

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

31 March 2020

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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma

31 March 2020

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Basal cell carcinoma: cell of origin, cancer stem cell hypothesis and stem cell markers

31 March 2020

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Identification of the cell lineage at the origin of basal cell carcinoma

31 March 2020

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Drugging Hedgehog: signaling the pathway to translation

31 March 2020

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

31 March 2020

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A paracrine requirement for hedgehog signalling in cancer

31 March 2020

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Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

31 March 2020

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Hedgehog signaling regulates nociceptive sensitization.

31 March 2020

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The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

31 March 2020

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Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord.

31 March 2020

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Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway

31 March 2020

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Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration

31 March 2020

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Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

31 March 2020

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Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium

31 March 2020

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Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins

31 March 2020

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Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord

31 March 2020

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The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex

31 March 2020

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Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog

31 March 2020

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The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

31 March 2020

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FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.

31 March 2020

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Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

31 March 2020

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Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings

31 March 2020

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12 December 2020

The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites.

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12 December 2020

Hedgehog beyond medulloblastoma and basal cell carcinoma

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12 December 2020

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

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12 December 2020

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

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12 December 2020

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

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12 December 2020

Cerebellar proteoglycans regulate sonic hedgehog responses during development.

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12 December 2020

Genetic analysis of hedgehog signalling in the Drosophila embryo

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12 December 2020

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

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12 December 2020

Structure and mechanism of RND-type multidrug efflux pumps

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12 December 2020

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

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12 December 2020

Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog.

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12 December 2020

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

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12 December 2020

Distinct roles of Central missing and Dispatched in sending the Hedgehog signal

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12 December 2020

Identifiers

DOI

10.1038/NRM3598

1 reference

PubMed ID

23719536

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23719536