(Q38148218)

English

The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches.

scientific article published on 02 October 2013

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24083449%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches (English)

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Europe PubMed Central

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26 February 2020

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26 February 2020

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26 February 2020

author name string

Orsola Vitagliano

1

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26 February 2020

Cristiana Indolfi

4

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26 February 2020

Paolo Indolfi

5

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26 February 2020

Fiorina Casale

6

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26 February 2020

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2 October 2013

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26 February 2020

Expert Review of Hematology

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26 February 2020

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26 February 2020

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26 February 2020

587-597

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26 February 2020

Apoptosis. Its significance in cancer and cancer therapy

1 reference

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The role of Bcl-2 family members in tumorigenesis

1 reference

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

1 reference

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BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

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tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

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Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

1 reference

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21 January 2018

BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions

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21 January 2018

Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

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21 January 2018

Development of anticancer drugs targeting the MAP kinase pathway

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21 January 2018

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

1 reference

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21 January 2018

Prognostic role of bcl-xL and p53 in childhood acute lymphoblastic leukemia (ALL).

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21 January 2018

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

1 reference

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21 January 2018

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

1 reference

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21 January 2018

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

1 reference

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21 January 2018

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.

1 reference

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21 January 2018

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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21 January 2018

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

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21 January 2018

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

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21 January 2018

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

1 reference

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21 January 2018

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

1 reference

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21 January 2018

Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage

1 reference

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21 January 2018

Have chemosensitizing strategies for multidrug-resistant childhood acute lymphoblastic leukemia come of age?

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21 January 2018

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

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21 January 2018

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

1 reference

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21 January 2018

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

1 reference

https://api.crossref.org/works/10.1586%2F17474086.2013.827415

21 January 2018

Effect of Ras inhibition in hematopoiesis and BCR/ABL leukemogenesis

1 reference

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21 January 2018

A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome

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21 January 2018

A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia

1 reference

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21 January 2018

Anti-leukemic activity of dasatinib in both p53(wild-type) and p53(mutated) B malignant cells

1 reference

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21 January 2018

MEK and the inhibitors: from bench to bedside

1 reference

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21 January 2018

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

1 reference

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21 January 2018

Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.

1 reference

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21 January 2018

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

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21 January 2018

Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

1 reference

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21 January 2018

ERK inhibition overcomes acquired resistance to MEK inhibitors.

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BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

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Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations

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21 January 2018

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