(Q38148498)

29 August 2017

The mechanisms linking adiposopathy to type 2 diabetes (English)

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29 August 2017

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Jichun Yang

1

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29 August 2017

Jihong Kang

series ordinal

2

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29 August 2017

Youfei Guan

series ordinal

3

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29 August 2017

1 October 2013

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29 August 2017

Frontiers of medicine

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29 August 2017

7

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29 August 2017

4

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29 August 2017

433-444

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https://scigraph.springernature.com/pub.10.1007/s11684-013-0288-9

29 August 2017

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cites work

Prevalence of diabetes among men and women in China

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Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men.

21 January 2018

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Adiposopathy: how do diet, exercise and weight loss drug therapies improve metabolic disease in overweight patients?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiposopathy, diabetes mellitus, and primary prevention of atherosclerotic coronary artery disease: treating "sick fat" through improving fat function with antidiabetes therapies

21 January 2018

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Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial

21 January 2018

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Teenage conceptions, abortions, and births in England, 1994-2003, and the national teenage pregnancy strategy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Lipid-induced insulin resistance: unravelling the mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Obesity, insulin resistance and free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adipocytokines: a bridge connecting obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin: a key player in obesity related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Mechanism of free fatty acid-induced insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Increased oxidative stress in obesity and its impact on metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Plasma interleukin-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged nonoverweight and overweight Japanese men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Cytokines in the Progression of Pancreatic β-Cell Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Leptin receptors expressed on pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

The hormone resistin links obesity to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin is expressed in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin induces rat insulinoma cell RINm5F apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Role of PPARgamma in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Expression of adiponectin receptors in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

High-fat diet induces increased tissue expression of TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Interleukin-1beta may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Leptin inhibits glycogen catabolism but does not modify acutely the suppressive effect of insulin on glucose production and glycogenolysis stimulated by 8-Br-cAMP in rat liver perfused in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Regulation of SOCS-3 expression by leptin and its co-localization with insulin receptor in rat skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin and insulin resistance in hepatocytes: resistin disturbs glycogen metabolism at the protein level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Activation of SOCS-3 by resistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin is expressed in human hepatocytes and induces insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Effects of resistin on skeletal glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin and its receptors in non-alcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Increases in adiponectin predict improved liver, but not peripheral, insulin sensitivity in severely obese women during weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Insulin-regulated expression of adiponectin receptors in muscle and fat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

NF-kappaB-inducing kinase (NIK) mediates skeletal muscle insulin resistance: blockade by adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Skeletal muscle NAMPT is induced by exercise in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Role of insulin and free fatty acids in the regulation of ob gene expression and plasma leptin in normal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Expression and regulation of nampt in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

Cloning, expression analysis, and regulatory mechanisms of bovine chemerin and chemerin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0288-9

[Evaluation of serum visfatin concentrations in children with nonalcoholic fatty liver disease].

21 January 2018

1 reference

12 December 2020

Autocrine effects of visfatin on hepatocyte sensitivity to insulin action

1 reference

12 December 2020

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, i

1 reference

12 December 2020

Programmed cell death induced by ceramide

1 reference

12 December 2020

Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells

1 reference

12 December 2020

Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake

1 reference

12 December 2020

[Overexpression of resistin affect 3T3-L1 adipocyte lipid metabolism].

1 reference

12 December 2020

Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis

1 reference

12 December 2020

Heterozygosity for leptin receptor (fa) accelerates hepatic triglyceride accumulation without hyperphagia in Zucker rats

1 reference

12 December 2020

Visceral adipose tissue visfatin in nonalcoholic fatty liver disease

1 reference

12 December 2020

Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes

1 reference

12 December 2020

Serum visfatin increases with progressive beta-cell deterioration

1 reference

12 December 2020

Chemerin regulates β-cell function in mice

1 reference

12 December 2020

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

1 reference

12 December 2020

Leptin and adiponectin regulate compensatory beta cell growth in accordance to overweight

1 reference

12 December 2020

Exercise increases adiponectin levels and insulin sensitivity in humans

1 reference

12 December 2020

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

1 reference

12 December 2020

10.1007/S11684-013-0288-9

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

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1 reference