(Q38151013)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

30 April 2021

G-quadruplex structures in the human genome as novel therapeutic targets (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

30 April 2021

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Marco Folini

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

author name string

Joanna Bidzinska

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Graziella Cimino-Reale

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

language of work or name

English

0 references

publication date

8 October 2013

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

30 April 2021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

30 April 2021

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

page(s)

12368-12395

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

27 February 2020

copyright license

1 reference

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

30 April 2021

0 references

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The application of DNA and RNA G-quadruplexes to therapeutic medicines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

5'-UTR RNA G-quadruplexes: translation regulation and targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The structures of quadruplex nucleic acids and their drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex nucleic acids as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

DNA secondary structures: stability and function of G-quadruplex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting non-B-form DNA in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex binding ligands: from naturally occurring to rationally designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Alternative lengthening of telomeres: remodeling the telomere architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomerase and the search for the end of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Pharmaceutical regulation of telomerase and its clinical potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplexes: from guanine gels to chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

High-resolution insight into G-overhang architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Polymorphism of human telomeric quadruplex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Structural insights into G-quadruplexes: towards new anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting pancreatic cancer with a G-quadruplex ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

POT1 and TRF2 cooperate to maintain telomeric integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomeres: the silence is broken

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

CpG-island promoters drive transcription of human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

TERRA: telomeric repeat-containing RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

hnRNP A1 associates with telomere ends and stimulates telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomeric repeat-containing RNA structure in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Structural basis of telomeric RNA quadruplex--acridine ligand recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

21 January 2018

G4 motifs in human genes

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

MYC oncogene in myeloid neoplasias.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The c-MYC NHE III(1): function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting MYC Expression through G-Quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Therapeutic targeting of c-KIT in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Putative DNA quadruplex formation within the human c-kit oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex recognition by bis-indole carboxamides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Structure and physiology of the RET receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting the RAS pathway in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting the Bcl-2 family for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The updated biology of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Making sense of G‐quadruplex and i‐motif functions in oncogene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

SRC: A Century of Science Brought to the Clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

5'-UTR G-quadruplex structures acting as translational repressors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Exploring mRNA 3'-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G‐quadruplex nucleic acids and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex structures: in vivo evidence and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Quantitative visualization of DNA G-quadruplex structures in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

G-quadruplex structures are stable and detectable in human genomic DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Targeting telomeres and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES181012368

Human telomere RNA and DNA form an intermolecular G-quadruplex

21 January 2018

1 reference

12 December 2020

Human telomeric RNA in G-quadruplex structure

1 reference

12 December 2020

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

1 reference

12 December 2020

Telomeres as targets for anticancer therapies.

1 reference

12 December 2020

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

12 December 2020

10.3390/MOLECULES181012368

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24108400%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

24108400

1 reference