(Q38151489)

29 August 2017

title

Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation (English)

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protein-protein interaction

29 August 2017

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Frankie Chi Fat Ko

1

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29 August 2017

Judy Wai Ping Yam

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

17 October 2013

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International Journal of Cancer

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published in

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29 August 2017

volume

135

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29 August 2017

issue

2

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29 August 2017

page(s)

264-269

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DLC1: a significant GAP in the cancer genome

29 August 2017

cites work

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Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity

21 January 2018

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START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology

21 January 2018

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START-GAP1/DLC1 is localized in focal adhesions through interaction with the PTB domain of tensin2.

21 January 2018

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The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

21 January 2018

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Rho GTPases in cancer cell biology

21 January 2018

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DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

21 January 2018

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Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.

21 January 2018

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Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver

21 January 2018

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Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

21 January 2018

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Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

21 January 2018

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DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

21 January 2018

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Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.

21 January 2018

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Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis

21 January 2018

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DLC1 negatively regulates angiogenesis in a paracrine fashion

21 January 2018

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DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism

21 January 2018

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The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

21 January 2018

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Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

21 January 2018

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A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors

21 January 2018

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Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells

21 January 2018

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Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo

21 January 2018

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DLC-1: a Rho GTPase-activating protein and tumour suppressor

21 January 2018

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Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function

21 January 2018

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Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

21 January 2018

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The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

21 January 2018

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Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function

21 January 2018

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21 January 2018

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The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis

21 January 2018

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Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

21 January 2018

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Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma

21 January 2018

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Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

21 January 2018

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DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

21 January 2018

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A PLCdelta1-binding protein, p122/RhoGAP, is localized in caveolin-enriched membrane domains and regulates caveolin internalization

21 January 2018

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Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

21 January 2018

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p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

21 January 2018

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DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

21 January 2018

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Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration

21 January 2018

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DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling

21 January 2018

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DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity

21 January 2018

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Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells

21 January 2018

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Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection

21 January 2018

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The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

21 January 2018

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PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.28505

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29 August 2017

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