(Q38155819)

29 August 2017

title

Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy? (English)

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29 August 2017

2

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29 August 2017

Joanne Lysaght

5

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Jacintha O'Sullivan

object named as

Jacintha N O'Sullivan

series ordinal

4

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author name string

Katie E O'Sullivan

series ordinal

1

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29 August 2017

Ciara O'Hanlon

series ordinal

3

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29 August 2017

publication date

1 March 2014

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Journal of gastrointestinal cancer

29 August 2017

published in

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29 August 2017

volume

45

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29 August 2017

issue

1

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29 August 2017

page(s)

1-11

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https://scigraph.springernature.com/pub.10.1007/s12029-013-9555-x

29 August 2017

exact match

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cites work

The two major epidemics of the twenty-first century: obesity and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The STATs of cancer--new molecular targets come of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

STATs in cancer inflammation and immunity: a leading role for STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Structure, function, and regulation of STAT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Structural bases of unphosphorylated STAT1 association and receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Jaks and STATs: biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Biology and significance of the JAK/STAT signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Signaling through the JAK/STAT pathway, recent advances and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

JAK-STAT signaling: from interferons to cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Specific inhibition of Stat3 signal transduction by PIAS3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Inflammation and cancer: back to Virchow?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Stat3: linking inflammation to (gastrointestinal) tumourigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Inflamed fat: what starts the fire?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Obesity and gastrointestinal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin: a review of its peripheral actions and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin action in intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin and gastro-intestinal malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin receptors expressed on pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Expression of leptin and leptin receptor isoforms in the human stomach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin signalling in pancreatic islets and clonal insulin-secreting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin receptor is involved in STAT3 activation in human colorectal adenoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin is a growth factor for colonic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

IL-6 signal transduction and its physiological roles: the signal orchestration model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Targeting the interleukin-6/Jak/stat pathway in human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Highly specific and quantitative activation of STATs in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Tyrosine phosphorylation-mediated signal transduction in MCP-1-induced macrophage activation: role for receptor dimerization, focal adhesion protein complex and JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Tumor endothelial inflammation predicts clinical outcome in diverse human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Differential expression of TNF-α signaling molecules and ERK1 in distal and proximal colonic tumors associated with obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Leptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Immunohistochemical study of nuclear factor-kappaB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Inflammatory gradient in Barrett's oesophagus: implications for disease complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The interleukin-8 pathway in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Negative regulation of the JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Signal transducer and activator of transcription 3 inhibitors: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Chemical probes that competitively and selectively inhibit Stat3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Inhibition of transcription factors with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Lack of toxicity of a STAT3 decoy oligonucleotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

T lymphocyte activation in visceral adipose tissue of patients with oesophageal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The association of gastric leptin with oesophageal inflammation and metaplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12029-013-9555-X

Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis.

21 January 2018

1 reference

12 December 2020

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

12 December 2020

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients

1 reference

12 December 2020

Cytokines and STAT signaling

1 reference

12 December 2020

Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells

1 reference

12 December 2020

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130

1 reference

12 December 2020

Expression of interleukin-8 correlates with vascularity in human gastric carcinomas.

1 reference

12 December 2020

STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells

1 reference

12 December 2020

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target

1 reference

12 December 2020

Biologic basis for interleukin-1 in disease

1 reference

12 December 2020

Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression.

1 reference

12 December 2020

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1 reference

12 December 2020

Interleukin-6 and its receptor are expressed in human intestinal epithelial cells

1 reference

12 December 2020

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

1 reference

12 December 2020

Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.

1 reference

12 December 2020

Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line.

1 reference

12 December 2020

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

1 reference

12 December 2020

IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines

1 reference

12 December 2020

Targeting STAT3 in cancer: how successful are we?

1 reference

12 December 2020

10.1007/S12029-013-9555-X

Identifiers

DOI

1 reference

29 August 2017

1 reference