(Q38156114)

29 August 2017

title

Suitability of digoxin as a P-glycoprotein probe: implications of other transporters on sensitivity and specificity (English)

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29 August 2017

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Ahmed M Nader

1

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29 August 2017

David R Foster

series ordinal

2

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29 August 2017

publication date

26 October 2013

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The Journal of Clinical Pharmacology

29 August 2017

published in

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29 August 2017

volume

54

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29 August 2017

issue

1

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29 August 2017

page(s)

3-13

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Role of P-glycoprotein in pharmacokinetics: clinical implications

29 August 2017

cites work

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The role of transporters in drug interactions

21 January 2018

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The drug transporter-metabolism alliance: uncovering and defining the interplay

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Transporters and drug therapy: implications for drug disposition and disease

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Importance of P-glycoprotein for drug-drug interactions

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Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression

21 January 2018

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Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

21 January 2018

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ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein

21 January 2018

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The MDR1 (ABCB1) gene polymorphism and its clinical implications

21 January 2018

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Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation

21 January 2018

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A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

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Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells

21 January 2018

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Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

21 January 2018

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

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Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

21 January 2018

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Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity

21 January 2018

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Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

21 January 2018

1 reference

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

21 January 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

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Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers

21 January 2018

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P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

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Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

21 January 2018

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Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver

21 January 2018

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Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

21 January 2018

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Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin

21 January 2018

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An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding

21 January 2018

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The complexity of intestinal absorption and exsorption of digoxin in rats.

21 January 2018

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Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

21 January 2018

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

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Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

21 January 2018

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Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

21 January 2018

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Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

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Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

21 January 2018

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Drug transporters in drug efficacy and toxicity

21 January 2018

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Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte.

21 January 2018

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Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

21 January 2018

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Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

21 January 2018

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Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

21 January 2018

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Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCPH.200

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29 August 2017

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