(Q37705351)

22 August 2017

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title

Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation (English)

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22 August 2017

Joseph D Ma

1

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22 August 2017

Shirley M Tsunoda

2

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22 August 2017

Joseph S Bertino

3

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22 August 2017

Meghana Trivedi

4

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22 August 2017

Keola K Beale

5

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22 August 2017

Anne N Nafziger

6

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22 August 2017

publication date

1 April 2010

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Clinical Pharmacokinetics

22 August 2017

published in

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22 August 2017

volume

49

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22 August 2017

issue

4

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22 August 2017

page(s)

223-237

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Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

Digitalis intoxication recognition and management

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

Digoxin pharmacokinetics and MDR1 genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11318000-000000000-00000

Herbal modulation of P-glycoprotein

21 January 2018

1 reference

12 December 2020

Relationship between loperamide-induced sedative effect and digoxin pharmacokinetics in healthy Japanese subjects

1 reference

12 December 2020

Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene

1 reference

12 December 2020

Bioequivalence evaluation of two different oral formulations of loperamide (Diarex Lactab vs Imodium capsules)

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12 December 2020

Multidrug resistance: molecular mechanisms and clinical relevance

1 reference

12 December 2020

Effect of ABCB1 (MDR1) 3435C >T and 2677G >A,T polymorphisms and P-glycoprotein inhibitors on salivary digoxin secretion in congestive heart failure patients

1 reference

12 December 2020

Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates

1 reference

12 December 2020

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

1 reference

12 December 2020

Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin

1 reference

12 December 2020

Pharmacokinetics of fexofenadine enantiomers in healthy subjects

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12 December 2020

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

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12 December 2020

Apricot extract inhibits the P-gp-mediated efflux of talinolol.

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12 December 2020

The MDR1 (ABCB1) gene polymorphism and its clinical implications

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12 December 2020

The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin

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12 December 2020

P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound.

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12 December 2020

The effect of rifampin administration on the disposition of fexofenadine

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12 December 2020

Energy-dependent transport of digoxin across renal tubular cell monolayers (LLC-PK1)

1 reference

12 December 2020

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

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12 December 2020

Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers

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12 December 2020

P-glycoprotein and surfactants: effect on intestinal talinolol absorption

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12 December 2020

Impact of MDR1 haplotypes derived from C1236T, G2677T/A and C3435T on the pharmacokinetics of single-dose oral digoxin in healthy Chinese volunteers

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12 December 2020

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.

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12 December 2020

Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers

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12 December 2020

Inhibitory effect of fruit extracts on P-glycoprotein-related efflux carriers: an in-vitro screening.

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12 December 2020

Interaction of ritonavir-boosted tipranavir with loperamide does not result in loperamide-associated neurologic side effects in healthy volunteers

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12 December 2020

P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

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12 December 2020

Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4.

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12 December 2020

Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.

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12 December 2020

Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping

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12 December 2020

Longitudinal assessment of a P-glycoprotein-mediated drug interaction of valspodar on digoxin

1 reference

12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

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12 December 2020

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

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12 December 2020

Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3

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12 December 2020

Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans

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12 December 2020

Management of rapid ventricular rate in acute atrial fibrillation.

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12 December 2020

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

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12 December 2020

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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12 December 2020

Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren

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12 December 2020

P-glycoprotein expression and function in circulating blood cells from normal volunteers.

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12 December 2020

On the clinical pharmacology of talinolol, a new beta 1-adrenoceptor blocking agent

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12 December 2020

An alternative hypothesis to involvement of intestinal P-glycoprotein as the cause for digoxin oral bioavailability enhancement by talinolol

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12 December 2020

Genetic variation in drug transporters in ethnic populations

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12 December 2020

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man

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12 December 2020

The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates

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12 December 2020

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

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12 December 2020

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.

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12 December 2020

Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase

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12 December 2020

Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice

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12 December 2020

Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities

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12 December 2020

Ritonavir decreases the nonrenal clearance of digoxin in healthy volunteers with known MDR1 genotypes

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12 December 2020

The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours.

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12 December 2020

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

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12 December 2020

Cardiovascular safety of fexofenadine HCl.

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12 December 2020

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

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12 December 2020

Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study

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12 December 2020

P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

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12 December 2020

P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro.

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12 December 2020

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

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12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

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12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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12 December 2020

Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein

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12 December 2020

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

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12 December 2020

In situ localization of P-glycoprotein (ABCB1) in human and rat brain

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12 December 2020

Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl

1 reference

12 December 2020

New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

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12 December 2020

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

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12 December 2020

Stereoselective disposition of talinolol in man.

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12 December 2020

Concentration-dependent exsorption of quinidine in the rat intestine

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12 December 2020

Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells

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12 December 2020

Increased drug delivery to the brain by P-glycoprotein inhibition

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12 December 2020

The complexity of intestinal absorption and exsorption of digoxin in rats.

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12 December 2020

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

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12 December 2020

Human intestinal P-glycoprotein activity estimated by the model substrate digoxin

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12 December 2020

Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans

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12 December 2020

In vitro metabolism of quinidine: the (3S)-3-hydroxylation of quinidine is a specific marker reaction for cytochrome P-4503A4 activity in human liver microsomes.

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

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12 December 2020

Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40.

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12 December 2020

Albumin influences expression and function of the membrane transporter P-glycoprotein in HK-2 human proximal tubular cells.

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12 December 2020

Structural model of the nucleotide-binding conserved component of periplasmic permeases

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12 December 2020

Expression of multidrug resistance proteins in rat and human chronic pancreatitis.

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12 December 2020

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

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12 December 2020

P-glycoprotein: so many ways to turn it on.

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12 December 2020

N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.

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12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

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12 December 2020

Problems and perspectives of phenotyping for drug-metabolizing enzymes in man.

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12 December 2020

Membrane topology of a cysteine-less mutant of human P-glycoprotein

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12 December 2020

Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms.

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12 December 2020

Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities

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12 December 2020

Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping

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12 December 2020

Intestinal drug transporter expression and the impact of grapefruit juice in humans

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12 December 2020

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

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12 December 2020

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

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12 December 2020

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.

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12 December 2020

Clinical pharmacokinetics of digoxin 1980.

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12 December 2020

Thyroxine (T4) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: contributory role of P-glycoprotein and organic anion transporting polypeptides.

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12 December 2020

Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

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12 December 2020

Elucidation of the structure of talinolol metabolites in man. Determination of talinolol and hydroxylated talinolol metabolites in urine and analysis of talinolol in serum

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12 December 2020

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

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12 December 2020

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

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12 December 2020

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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12 December 2020

The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects

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12 December 2020

The effect of bosentan on the pharmacokinetics of digoxin in healthy male subjects

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12 December 2020

Transport characteristics of fexofenadine in the Caco-2 cell model

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12 December 2020

Digitalis pharmacokinetics and metabolism

1 reference

12 December 2020

Irinotecan pathway genotype analysis to predict pharmacokinetics

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12 December 2020

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

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12 December 2020

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

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12 December 2020

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

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12 December 2020

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

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12 December 2020

No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract

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12 December 2020

Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

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12 December 2020

Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug

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12 December 2020

Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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12 December 2020

Genotyping and phenotyping the cytochrome p-450 enzymes

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12 December 2020

Lack of dose-dependent effects of itraconazole on the pharmacokinetic interaction with fexofenadine

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12 December 2020

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

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12 December 2020

Effect of St John's wort on the pharmacokinetics of fexofenadine

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12 December 2020

Influence of single-nucleotide polymorphisms in the multidrug resistance-1 gene on the cellular export of nelfinavir and its clinical implication for highly active antiretroviral therapy

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12 December 2020

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

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12 December 2020

Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors

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12 December 2020

PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS.

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12 December 2020

Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.

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12 December 2020

Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver

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12 December 2020

Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans

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12 December 2020

Biochemistry. Through a mirror, differently.

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12 December 2020

A "silent" polymorphism in the MDR1 gene changes substrate specificity

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12 December 2020

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects

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12 December 2020

ABCB1 pharmacogenetics: progress, pitfalls, and promise

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12 December 2020

Clinical relevance of P-glycoprotein in drug therapy

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12 December 2020

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

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12 December 2020

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

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12 December 2020

Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes

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12 December 2020

Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine

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12 December 2020

Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man.

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12 December 2020

In vivo modulation of CYP enzymes by quinidine and rifampin

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12 December 2020

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability

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12 December 2020

Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein

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12 December 2020

The actions of talinolol, a beta 1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction

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12 December 2020

Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity

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12 December 2020

Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers

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12 December 2020

Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism

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12 December 2020

Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro

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12 December 2020

Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

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12 December 2020

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

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12 December 2020

Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria

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12 December 2020

Mammalian ABC transporters in health and disease

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12 December 2020

Grapefruit juice ingestion significantly reduces talinolol bioavailability

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12 December 2020

Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion

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12 December 2020

The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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12 December 2020

Characterization of the human MDR1 gene

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12 December 2020

Variability of intestinal expression of P-glycoprotein in healthy volunteers as described by absorption of talinolol from four bioequivalent tablets

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12 December 2020

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

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12 December 2020

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients

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12 December 2020

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

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12 December 2020

Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells

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12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

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12 December 2020

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

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12 December 2020

Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

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12 December 2020

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

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12 December 2020

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

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12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

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12 December 2020

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

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12 December 2020

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

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12 December 2020

Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine

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12 December 2020

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

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12 December 2020

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

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12 December 2020

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

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12 December 2020

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects

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12 December 2020

Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol

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12 December 2020

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

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12 December 2020

The effect of digoxin on mortality and morbidity in patients with heart failure

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12 December 2020

Grapefruit Juice–Drug Interactions: Grapefruit Juice and Its Components Inhibit P‐Glycoprotein (ABCB1) Mediated Transport of Talinolol in Caco‐2 Cells

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12 December 2020

Some Considerations as to the Determination and Significance of Biologic Half-Life

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12 December 2020

Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).

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12 December 2020

CYP3A and P-glycoprotein activity induction with St. John's Wort in healthy volunteers from 6 ethnic populations

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12 December 2020

Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans.

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12 December 2020

Effects of uptake and efflux transporter inhibition on erythromycin breath test results

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12 December 2020

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

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12 December 2020

10.2165/11318000-000000000-00000

Identifiers

DOI

1 reference

Dimensions Publication ID

22 August 2017

1013496208

0 references

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