(Q45188831)

10 December 2017

title

Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination (English)

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10 December 2017

1

Evan D Kharasch

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10 December 2017

Alysa Walker

2

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10 December 2017

Christine Hoffer

series ordinal

3

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10 December 2017

Pamela Sheffels

series ordinal

4

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10 December 2017

publication date

1 January 2005

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The Journal of Clinical Pharmacology

10 December 2017

published in

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10 December 2017

volume

45

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10 December 2017

issue

1

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10 December 2017

page(s)

79-88

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The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

10 December 2017

cites work

1 reference

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Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

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In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

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Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

21 January 2018

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The human CYP3A subfamily: practical considerations

21 January 2018

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Genetic contribution to variable human CYP3A-mediated metabolism

21 January 2018

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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

21 January 2018

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Dietary Effects on Drug Metabolism and Transport

21 January 2018

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Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

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P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

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Impact of drug transporter studies on drug discovery and development

21 January 2018

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Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

21 January 2018

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21 January 2018

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Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

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The erythromycin breath test for the prediction of drug clearance

21 January 2018

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Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualization

21 January 2018

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Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity.

21 January 2018

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Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin

21 January 2018

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An evaluation of the suitability of intravenous midazolam as an in vivo marker for hepatic cytochrome P4503A activity

21 January 2018

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Physiologic and temporal variation in hepatic elimination of midazolam.

21 January 2018

1 reference

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Exercise alters the pharmacokinetics of midazolam

21 January 2018

1 reference

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The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

21 January 2018

1 reference

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A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans

21 January 2018

1 reference

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Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity

21 January 2018

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Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis

21 January 2018

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Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

21 January 2018

1 reference

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

The effect of rifampin administration on the disposition of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine

21 January 2018

1 reference

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Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

21 January 2018

1 reference

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Grapefruit juice activates P-glycoprotein-mediated drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Effect of food on the bioavailability of fexofenadine hydrochloride (MDL 16455A).

21 January 2018

1 reference

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Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

1 reference

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Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins

21 January 2018

1 reference

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Effect of St John's wort on the pharmacokinetics of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

21 January 2018

1 reference

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Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

21 January 2018

1 reference

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Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

21 January 2018

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Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40.

21 January 2018

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Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270004269705

21 January 2018

Identifiers

DOI

10.1177/0091270004269705

1 reference

release_zivm2wtdrzecbjowz4lmodtgtm

10 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zivm2wtdrzecbjowz4lmodtgtm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference