(Q28269209)

1

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Kenneth T Thummel

3

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Vishal S Narang

4

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Christine J Hoffer

5

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Jashvant D Unadkat

The Journal of Clinical Pharmacology

6

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language of work or name

English

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publication date

November 2006

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published in

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volume

46

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issue

11

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page(s)

1313-9

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cites work

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270006292625

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

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Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".

21 January 2018

1 reference

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The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

21 January 2018

1 reference

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Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1.

21 January 2018

1 reference

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Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination

21 January 2018

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Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

21 January 2018

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Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

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Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

21 January 2018

1 reference

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Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Grapefruit juice activates P-glycoprotein-mediated drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Pharmacokinetic and safety profile of desloratadine and fexofenadine when coadministered with azithromycin: a randomized, placebo-controlled, parallel-group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Effect of St John's wort on the pharmacokinetics of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

The effect of rifampin administration on the disposition of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Effect of Mibefradil on CYP3A4 In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006292625