(Q46743429)

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Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study (English)

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

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M F Hebert

1

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

T R Easterling

2

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

B Kirby

3

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

D B Carr

4

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

M L Buchanan

5

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

T Rutherford

6

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

K E Thummel

7

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

D P Fishbein

8

1 reference

Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

J D Unadkat

9

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

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20 February 2008

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

Clinical Pharmacology & Therapeutics

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18288078

84

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

248-253

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

Physiologic changes in pregnancy and their effect on drug disposition

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MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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Comparison of midazolam and simvastatin as cytochrome P450 3A probes

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The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

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Genotype???phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women

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Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities

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Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women

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Pharmacokinetics of nelfinavir in HIV-1-infected pregnant and nonpregnant women

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

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Itraconazole decreases renal clearance of digoxin

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24-hour creatinine clearance during the third trimester of normal pregnancy

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Serial changes in 24 hour creatinine clearance during normal menstrual cycles and the first trimester of pregnancy

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Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers

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Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

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10.1038/CLPT.2008.1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18288078

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