(Q38195930)

30 August 2017

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title

More than just a filler - the role of hyaluronan for skin homeostasis (English)

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30 August 2017

1

Ulf Anderegg

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30 August 2017

Jan C Simon

2

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30 August 2017

Marco Averbeck

series ordinal

3

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30 August 2017

publication date

1 May 2014

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30 August 2017

published in

Experimental Dermatology

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30 August 2017

volume

23

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30 August 2017

issue

5

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30 August 2017

page(s)

295-303

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Hyaluronan-dependent pericellular matrix

30 August 2017

cites work

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Hyaluronan: from extracellular glue to pericellular cue.

21 January 2018

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Hyaluronan-binding proteins: tying up the giant

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Hyaluronan: polysaccharide chaos to protein organisation

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Intracellular localization of hyaluronan in proliferating cells

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Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix

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Hyaluronan and tumor growth

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The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association

21 January 2018

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Imaging and tracking of single hyaluronan molecules diffusing in solution

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The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching

21 January 2018

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Extended, relaxed, and condensed conformations of hyaluronan observed by atomic force microscopy

21 January 2018

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Acylation of CD44 and its association with lipid rafts are required for receptor and hyaluronan endocytosis

21 January 2018

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Experimental approaches to hyaluronan structure

21 January 2018

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Chemically-modified HA for therapy and regenerative medicine

21 January 2018

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Engineering a clinically-useful matrix for cell therapy

21 January 2018

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Design of graded biomimetic osteochondral composite scaffolds

21 January 2018

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Regenerative potential of glycosaminoglycans for skin and bone.

21 January 2018

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HA modulation of epidermal morphogenesis in an organotypic keratinocyte-fibroblast co-culture model

21 January 2018

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Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin.

21 January 2018

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Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes.

21 January 2018

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Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4.

21 January 2018

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CD44 variant isoform v10 is expressed on tumor-infiltrating lymphocytes and mediates hyaluronan-independent heterotypic cell-cell adhesion to melanoma cells

21 January 2018

1 reference

Regenerative medicine in dermatology: biomaterials, tissue engineering, stem cells, gene transfer and beyond

21 January 2018

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The anti-ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis Episkin™.

21 January 2018

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Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury

21 January 2018

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Hyaluronan in morphogenesis

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Hyaluronan: its nature, distribution, functions and turnover

21 January 2018

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The acid mucopolysaccharides of mammalian skin.

21 January 2018

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Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe

21 January 2018

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Hyaluronan and CD44 in psoriatic skin. Intense staining for hyaluronan on dermal capillary loops and reduced expression of CD44 and hyaluronan in keratinocyte-leukocyte interfaces

21 January 2018

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EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation

21 January 2018

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Hyaluronan in skin: aspects of aging and its pharmacologic modulation

21 January 2018

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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation

21 January 2018

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Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo

21 January 2018

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Immunologic roles of hyaluronan

21 January 2018

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Molecular stenting with a crosslinked hyaluronan derivative inhibits collagen gel contraction.

21 January 2018

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Mammalian hyaluronan synthases

21 January 2018

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Hyaluronan synthesis induces microvillus-like cell surface protrusions

21 January 2018

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CD44: from adhesion molecules to signalling regulators

21 January 2018

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Immunological functions of hyaluronan and its receptors in the lymphatics

21 January 2018

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Hyaluronan-cell interactions in cancer and vascular disease

21 January 2018

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Signaling properties of hyaluronan receptors

21 January 2018

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RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53.

21 January 2018

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Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: inter-alpha-trypsin inhibitor is crucial to structure and function

21 January 2018

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Hyaluronan cross-linking: a protective mechanism in inflammation?

21 January 2018

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Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis

21 January 2018

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TSG-6 modulates the interaction between hyaluronan and cell surface CD44.

21 January 2018

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The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor.

21 January 2018

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Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion

21 January 2018

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Hyaluronan matrices in pathobiological processes

21 January 2018

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Intracellular hyaluronan: a new frontier for inflammation?

21 January 2018

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Cyclin D3 mediates synthesis of a hyaluronan matrix that is adhesive for monocytes in mesangial cells stimulated to divide in hyperglycemic medium

21 January 2018

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Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy.

21 January 2018

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Intracellular hyaluronan in arterial smooth muscle cells: association with microtubules, RHAMM, and the mitotic spindle

21 January 2018

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The six hyaluronidase-like genes in the human and mouse genomes

21 January 2018

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Degradation of newly synthesized high molecular mass hyaluronan in the epidermal and dermal compartments of human skin in organ culture

21 January 2018

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The many ways to cleave hyaluronan.

21 January 2018

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Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation

21 January 2018

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Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

21 January 2018

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Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblast proliferation

21 January 2018

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Disaccharide analysis of the skin glycosaminoglycans in systemic sclerosis

21 January 2018

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Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases

21 January 2018

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Hyaluronan minimizes effects of UV irradiation on human keratinocytes

21 January 2018

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Molecular cloning of human hyaluronan synthase

21 January 2018

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Molecular cloning and characterization of a putative mouse hyaluronan synthase

21 January 2018

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Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

21 January 2018

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Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

21 January 2018

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21 January 2018

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The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

21 January 2018

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Transcriptional and post-translational regulation of hyaluronan synthesis.

21 January 2018

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Modulation of hyaluronan synthase activity in cellular membrane fractions

21 January 2018

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Hyaluronan synthases: a decade-plus of novel glycosyltransferases

21 January 2018

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Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions

21 January 2018

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Expression of human hyaluronan synthases in response to external stimuli

21 January 2018

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Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: impact on melanoma cell proliferation

21 January 2018

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Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling

21 January 2018

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Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

21 January 2018

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Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat.

21 January 2018

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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

21 January 2018

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Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.

21 January 2018

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Differential effect of transforming growth factor beta (TGF-beta) on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan synthase 1 activation

21 January 2018

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Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids.

21 January 2018

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Hyaluronan catabolism: a new metabolic pathway

21 January 2018

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CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

21 January 2018

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Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.

21 January 2018

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KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

21 January 2018

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Hyal2--less active, but more versatile?

21 January 2018

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Hyaluronan and its catabolic products in tissue injury and repair

21 January 2018

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Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines

21 January 2018

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Purification, cloning, and expression of human plasma hyaluronidase

21 January 2018

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Hyaluronidases--a group of neglected enzymes

21 January 2018

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Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase

21 January 2018

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CD44-mediated uptake and degradation of hyaluronan

21 January 2018

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Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism

21 January 2018

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Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

21 January 2018

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Cell-matrix interactions of in vitro human skin fibroblasts upon addition of hyaluronan

21 January 2018

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The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

21 January 2018

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Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells

21 January 2018

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Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells

21 January 2018

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The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan

21 January 2018

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Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly

21 January 2018

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Hyaluronan fragments stimulate endothelial recognition of injury through TLR4.

21 January 2018

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Hyaluronan--magic glue for the regulation of the immune response?

21 January 2018

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Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4.

21 January 2018

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Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX

21 January 2018

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Synthesis and degradation of hyaluronic acid in the cultured fibroblasts of Marfan's disease

21 January 2018

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Cutaneous mucinosis associated with dermatomyositis and nephrogenic fibrosing dermopathy: fibroblast hyaluronan synthesis and the effect of patient serum.

21 January 2018

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Aberrant serum hyaluronan and hyaluronidase levels in scleroderma

21 January 2018

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Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes

21 January 2018

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Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice

21 January 2018

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Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.

21 January 2018

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The initial and subsequent inflammatory events during calcium oxalate lithiasis

21 January 2018

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HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

21 January 2018

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Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid

21 January 2018

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Hyaluronan-oligosaccharide-induced transcription of metalloproteases

21 January 2018

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4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors.

21 January 2018

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Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

21 January 2018

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Hyaluronan, CD44 and versican in epidermal keratinocyte tumours

21 January 2018

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Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

21 January 2018

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Wound repair and regeneration

21 January 2018

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Hyaluronan affects protein and collagen synthesis by in vitro human skin fibroblasts.

21 January 2018

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Studies in fetal wound healing. IV. Hyaluronic acid-stimulating activity distinguishes fetal wound fluid from adult wound fluid

21 January 2018

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Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid

21 January 2018

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Interaction of wingless protein (Wnt), transforming growth factor-beta1, and hyaluronan production in fetal and postnatal fibroblasts

21 January 2018

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Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism

21 January 2018

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Functions of hyaluronan in wound repair

21 January 2018

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Expression of proteoglycans and hyaluronan during wound healing

21 January 2018

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Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation

21 January 2018

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Hyaluronan Synthesis Mediates the Fibrotic Response of Keratocytes to Transforming Growth Factor β

21 January 2018

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Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing.

21 January 2018

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Angiogenesis induced by degradation products of hyaluronic acid.

21 January 2018

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CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.

21 January 2018

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Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

21 January 2018

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Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin.

21 January 2018

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Hyaluronan structures synthesized by rat mesangial cells in response to hyperglycemia induce monocyte adhesion

21 January 2018

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Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration

21 January 2018

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Understanding, avoiding, and managing dermal filler complications

21 January 2018

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The role of hyaluronic acid in wound healing: assessment of clinical evidence

21 January 2018

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Biomimetic materials for tissue engineering

21 January 2018

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Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages

21 January 2018

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Prevention of anti-microbial peptide LL-37-induced apoptosis and ATP release in the urinary bladder by a modified glycosaminoglycan

21 January 2018

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Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFβ(1) signaling and prevents TGFβ(1)-induced myofibroblast differentiation.

21 January 2018

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Allergic reaction to hyaluronidase: a rare cause of orbital inflammation after cataract surgery

21 January 2018

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Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis

21 January 2018

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Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling

21 January 2018

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Extracellular matrix molecules: potential targets in pharmacotherapy.

21 January 2018

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Suppression of hyaluronan synthase 2 expression reflects the atrophogenic potential of glucocorticoids

21 January 2018

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Dexamethasone regulation of glycosaminoglycan synthesis in cultured human skin fibroblasts. Similar effects of glucocorticoid and thyroid hormones

21 January 2018

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Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan synthases (HAS): hydrocortisone inhibits HAS1 activation by blocking the p38 mitogen-activated protein kinase signalling pathway

21 January 2018

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Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.

21 January 2018

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The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene

21 January 2018

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Hyaluronate accumulation in human epidermis treated with retinoic acid in skin organ culture

21 January 2018

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4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

21 January 2018

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High-fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin

21 January 2018

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Hyaluronan accumulation is elevated in cultures of low density lipoprotein receptor-deficient cells and is altered by manipulation of cell cholesterol content

21 January 2018

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Hyaluronidase expression in human skin fibroblasts

21 January 2018

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Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair

21 January 2018

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Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1.

21 January 2018

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Keratinocyte-fibroblast interactions in wound healing

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/EXD.12370

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30 August 2017

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