(Q38197885)

30 August 2017

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title

Prime movers: the mechanochemistry of mitotic kinesins (English)

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30 August 2017

Andrew McAinsh

2

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Robert A Cross

object named as

Robert A Cross

series ordinal

1

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language of work or name

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1 April 2014

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Nature Reviews Molecular Cell Biology

30 August 2017

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30 August 2017

15

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30 August 2017

257-271

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30 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrm3768

30 August 2017

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cites work

Force generation by microtubule assembly/disassembly in mitosis and related movements

1 reference

Physical properties determining self-organization of motors and microtubules

31 March 2020

1 reference

Self-organization in cell biology: a brief history

31 March 2020

1 reference

Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules

31 March 2020

1 reference

Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors

31 March 2020

1 reference

Force and length in the mitotic spindle

31 March 2020

1 reference

Mitotic motors and chromosome segregation: the mechanism of anaphase B.

31 March 2020

1 reference

Slide-and-cluster models for spindle assembly

31 March 2020

1 reference

Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton

31 March 2020

1 reference

Exotic mitotic mechanisms

31 March 2020

1 reference

Functions and mechanics of dynein motor proteins

31 March 2020

1 reference

Kinesin tail domains are intrinsically disordered.

31 March 2020

1 reference

A standardized kinesin nomenclature

31 March 2020

1 reference

Kinesin superfamily motor proteins and intracellular transport

31 March 2020

1 reference

The case for a common ancestor: kinesin and myosin motor proteins and G proteins

31 March 2020

1 reference

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

31 March 2020

1 reference

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether

31 March 2020

1 reference

Traffic control: regulation of kinesin motors.

31 March 2020

1 reference

Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E.

31 March 2020

1 reference

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity

31 March 2020

1 reference

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

31 March 2020

1 reference

Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin

31 March 2020

1 reference

The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A.

31 March 2020

1 reference

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.

31 March 2020

1 reference

Kinesin's cover-neck bundle folds forward to generate force

31 March 2020

1 reference

ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement

31 March 2020

1 reference

Force generation by kinesin and myosin cytoskeletal motor proteins

31 March 2020

1 reference

Structural basis for the ATP-induced isomerization of kinesin

31 March 2020

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An atomic-level mechanism for activation of the kinesin molecular motors

31 March 2020

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A structural change in the kinesin motor protein that drives motility

31 March 2020

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High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations

31 March 2020

1 reference

A seesaw model for intermolecular gating in the kinesin motor protein

31 March 2020

1 reference

Thermodynamic properties of the kinesin neck-region docking to the catalytic core

31 March 2020

1 reference

Feedback of the kinesin-1 neck-linker position on the catalytic site

31 March 2020

1 reference

Role of the kinesin neck linker and catalytic core in microtubule-based motility

31 March 2020

1 reference

Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet?

31 March 2020

1 reference

One-dimensional Brownian motion of charged nanoparticles along microtubules: a model system for weak binding interactions

31 March 2020

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Processivity of the single-headed kinesin KIF1A through biased binding to tubulin

31 March 2020

1 reference

Electrostatically biased binding of kinesin to microtubules

31 March 2020

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Intramolecular strain coordinates kinesin stepping behavior along microtubules

31 March 2020

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Chemomechanical coupling of the forward and backward steps of single kinesin molecules

31 March 2020

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Mechanics of the kinesin step.

31 March 2020

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Stepping and stretching. How kinesin uses internal strain to walk processively

31 March 2020

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What kinesin does at roadblocks: the coordination mechanism for molecular walking

31 March 2020

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Interhead tension determines processivity across diverse N-terminal kinesins

31 March 2020

1 reference

The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

31 March 2020

1 reference

Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner

31 March 2020

1 reference

The molecular basis for kinesin functional specificity during mitosis.

31 March 2020

1 reference

Mechanisms of centrosome separation and bipolar spindle assembly

31 March 2020

1 reference

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

31 March 2020

1 reference

31 March 2020

1 reference

The bipolar assembly domain of the mitotic motor kinesin-5

31 March 2020

1 reference

A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

31 March 2020

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Microtubule cross-linking triggers the directional motility of kinesin-5

31 March 2020

1 reference

Homotetrameric form of Cin8p, a Saccharomyces cerevisiae kinesin-5 motor, is essential for its in vivo function

31 March 2020

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Allosteric inhibition of kinesin-5 modulates its processive directional motility.

31 March 2020

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The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

31 March 2020

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Directional switching of the kinesin Cin8 through motor coupling

31 March 2020

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Regulation of bi-directional movement of single kinesin-5 Cin8 molecules

31 March 2020

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Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo

31 March 2020

1 reference

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

31 March 2020

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Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers

31 March 2020

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Load-dependent release limits the processive stepping of the tetrameric Eg5 motor

31 March 2020

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Walking, hopping, diffusing and braking modes of kinesin-5.

31 March 2020

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Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.

31 March 2020

1 reference

Single-headed mode of kinesin-5.

31 March 2020

1 reference

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence

31 March 2020

1 reference

Mechanisms of mitotic spindle assembly and function

31 March 2020

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Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly

31 March 2020

1 reference

Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly

31 March 2020

1 reference

Kinesin-12 differentially affects spindle assembly depending on its microtubule substrate

31 March 2020

1 reference

Kif15 cooperates with eg5 to promote bipolar spindle assembly

31 March 2020

1 reference

Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis.

31 March 2020

1 reference

The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development

31 March 2020

1 reference

Nonautonomous movement of chromosomes in mitosis

31 March 2020

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31 March 2020

1 reference

The role of Hklp2 in the stabilization and maintenance of spindle bipolarity

31 March 2020

1 reference

A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd.

31 March 2020

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Bidirectional power stroke by ncd kinesin

31 March 2020

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The Ncd tail domain promotes microtubule assembly and stability

31 March 2020

1 reference

The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism.

31 March 2020

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Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart

31 March 2020

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The mitotic kinesin-14 Ncd drives directional microtubule-microtubule sliding.

31 March 2020

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Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14

31 March 2020

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Microtubule motors in mitosis

31 March 2020

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Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.

31 March 2020

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NCD activation of tubulin polymerization

31 March 2020

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Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site

31 March 2020

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Kar3Vik1 mechanochemistry is inhibited by mutation or deletion of the C terminus of the Vik1 subunit.

31 March 2020

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Finding the middle ground: how kinetochores power chromosome congression.

31 March 2020

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Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint

31 March 2020

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Chromosomes can congress to the metaphase plate before biorientation

31 March 2020

1 reference

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

31 March 2020

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CENP-E function at kinetochores is essential for chromosome alignment.

31 March 2020

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The mitotic kinesin CENP-E is a processive transport motor.

31 March 2020

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Microtubule capture by mitotic kinesin centromere protein E (CENP-E).

31 March 2020

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The ATPase cycle of the mitotic motor CENP-E.

31 March 2020

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Chromosome congression in the absence of kinetochore fibres

31 March 2020

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The multiple talents of kinesin-8.

31 March 2020

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Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control

31 March 2020

1 reference

The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression

31 March 2020

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A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases

31 March 2020

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Kif18B interacts with EB1 and controls astral microtubule length during mitosis

31 March 2020

1 reference

Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle

31 March 2020

1 reference

Move in for the kill: motile microtubule regulators

31 March 2020

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The kinesin-8 Kif18A dampens microtubule plus-end dynamics.

31 March 2020

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Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension

31 March 2020

1 reference

Insight into the molecular mechanism of the multitasking kinesin-8 motor

31 March 2020

1 reference

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment

31 March 2020

1 reference

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases

31 March 2020

1 reference

Kinesin-8 is a low-force motor protein with a weakly bound slip state

31 March 2020

1 reference

The highly processive kinesin-8, Kip3, switches microtubule protofilaments with a bias toward the left

31 March 2020

1 reference

Molecular crowding creates traffic jams of kinesin motors on microtubules

31 March 2020

1 reference

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation

31 March 2020

1 reference

A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

31 March 2020

1 reference

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work

31 March 2020

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Efficient mitosis in human cells lacking poleward microtubule flux

31 March 2020

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Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

31 March 2020

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MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover

31 March 2020

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Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

31 March 2020

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The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends.

31 March 2020

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Multi-talented MCAK: Microtubule depolymerizer with a strong grip.

31 March 2020

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Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

31 March 2020

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Mitotic kinesin CENP-E promotes microtubule plus-end elongation

31 March 2020

1 reference

Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle

31 March 2020

1 reference

Chromokinesins: localization-dependent functions and regulation during cell division

31 March 2020

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Microtubule movements on the arms of mitotic chromosomes: polar ejection forces quantified in vitro

31 March 2020

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Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis

31 March 2020

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The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly

31 March 2020

1 reference

The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles

31 March 2020

1 reference

The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement

31 March 2020

1 reference

Xkid, a chromokinesin required for chromosome alignment on the metaphase plate

31 March 2020

1 reference

The human chromokinesin Kid is a plus end-directed microtubule-based motor

31 March 2020

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Elevated polar ejection forces stabilize kinetochore-microtubule attachments

31 March 2020

1 reference

Kinesin family in murine central nervous system

31 March 2020

1 reference

Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein

31 March 2020

1 reference

Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis

31 March 2020

2 references

31 March 2020

12 December 2020

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

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Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends

31 March 2020

1 reference

Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis

31 March 2020

1 reference

Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

31 March 2020

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31 March 2020

Biophysics of mitosis

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Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis

31 March 2020

1 reference

Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast

31 March 2020

1 reference

Kinesin-5 acts as a brake in anaphase spindle elongation

31 March 2020

1 reference

The 3Ms of central spindle assembly: microtubules, motors and MAPs

31 March 2020

1 reference

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

31 March 2020

1 reference

Cytokinesis microtubule organisers at a glance

31 March 2020

1 reference

Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody

31 March 2020

1 reference

Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis

31 March 2020

1 reference

ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration

31 March 2020

1 reference

Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation

31 March 2020

1 reference

A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps.

31 March 2020

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KIF4 regulates midzone length during cytokinesis

31 March 2020

1 reference

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

31 March 2020

1 reference

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase

31 March 2020

1 reference

Five challenges to bringing single-molecule force spectroscopy into living cells

31 March 2020

1 reference

How do anti-mitotic drugs kill cancer cells?

31 March 2020

1 reference

Mitosis-targeting therapies: a troubleshooting guide

31 March 2020

1 reference

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes

31 March 2020

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31 March 2020

1 reference

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

31 March 2020

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Monastrol stabilises an attached low-friction mode of Eg5.

31 March 2020

1 reference

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly

31 March 2020

1 reference

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

31 March 2020

1 reference

Kinesin inhibitor marches toward first-in-class pivotal trial.

31 March 2020

1 reference

Microtubule motors: a new hope for kinesin-5 inhibitors?

31 March 2020

1 reference

A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops

31 March 2020

1 reference

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.

31 March 2020

1 reference

Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization.

31 March 2020

1 reference

A new model for binding of kinesin 13 to curved microtubule protofilaments

31 March 2020

1 reference

Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases

31 March 2020

1 reference

A kinesin-13 mutant catalytically depolymerizes microtubules in ADP

31 March 2020

1 reference

Structure of a kinesin-tubulin complex and implications for kinesin motility

31 March 2020

1 reference

An ATP gate controls tubulin binding by the tethered head of kinesin-1.

31 March 2020

1 reference

Kinetochore fiber formation in animal somatic cells: dueling mechanisms come to a draw

31 March 2020

1 reference

Kinetochore microtubule dynamics and the metaphase-anaphase transition

31 March 2020

1 reference

Astral and spindle forces in PtK2 cells during anaphase B: a laser microbeam study

31 March 2020

1 reference

12 December 2020

Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations

1 reference

12 December 2020

Muscle structure and theories of contraction

1 reference

12 December 2020

Focusing on spindle poles

1 reference

12 December 2020

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

1 reference

12 December 2020

Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3768

1 reference

PubMed ID

24651543

Dimensions Publication ID

30 August 2017

0 references

1 reference

PubMed ID

24651543