(Q38197886)

30 August 2017

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title

The integrin adhesome: from genes and proteins to human disease (English)

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30 August 2017

2

Reinhard Fässler

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30 August 2017

Sabina E Winograd-Katz

series ordinal

1

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30 August 2017

Benjamin Geiger

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3

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30 August 2017

Kyle R Legate

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4

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30 August 2017

language of work or name

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1 April 2014

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Nature Reviews Molecular Cell Biology

30 August 2017

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30 August 2017

15

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30 August 2017

273-288

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30 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrm3769

30 August 2017

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cites work

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

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Integrins: versatility, modulation, and signaling in cell adhesion

31 March 2020

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Functional atlas of the integrin adhesome

31 March 2020

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The switchable integrin adhesome.

31 March 2020

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Molecular architecture and function of matrix adhesions

31 March 2020

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Environmental sensing through focal adhesions

31 March 2020

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β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

31 March 2020

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Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions

31 March 2020

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Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

31 March 2020

1 reference

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

31 March 2020

1 reference

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

31 March 2020

1 reference

Opening the floodgates: proteomics and the integrin adhesome

31 March 2020

1 reference

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

31 March 2020

1 reference

Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site

31 March 2020

1 reference

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

31 March 2020

1 reference

Integrins in invasive growth

31 March 2020

1 reference

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

31 March 2020

1 reference

Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction

31 March 2020

1 reference

The genetic association database

31 March 2020

1 reference

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.

31 March 2020

1 reference

The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

31 March 2020

1 reference

Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information

31 March 2020

1 reference

Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models

31 March 2020

1 reference

Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia

31 March 2020

1 reference

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex

31 March 2020

1 reference

A novel homozygous splice junction mutation in GPIIb associated with alternative splicing, nonsense-mediated decay of GPIIb-mRNA, and type II Glanzmann's thrombasthenia.

31 March 2020

1 reference

Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi

31 March 2020

1 reference

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

31 March 2020

1 reference

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

31 March 2020

1 reference

Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice

31 March 2020

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Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice

31 March 2020

1 reference

Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation

31 March 2020

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Cooperation between VEGF and beta3 integrin during cardiac vascular development

31 March 2020

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Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

31 March 2020

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A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function

31 March 2020

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Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.

31 March 2020

1 reference

Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions

31 March 2020

1 reference

Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins

31 March 2020

1 reference

Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency

31 March 2020

1 reference

Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins

31 March 2020

1 reference

A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice

31 March 2020

1 reference

Spontaneous skin ulceration and defective T cell function in CD18 null mice

31 March 2020

1 reference

Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice

31 March 2020

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Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells

31 March 2020

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Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in 2 integrin-deficient mice

31 March 2020

1 reference

A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice

31 March 2020

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Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

31 March 2020

1 reference

Regulation of wound healing by growth factors and cytokines

31 March 2020

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Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation

31 March 2020

1 reference

The Kindlins: subcellular localization and expression during murine development

31 March 2020

1 reference

The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell

31 March 2020

1 reference

LAD-III, a novel group of leukocyte integrin activation deficiencies.

31 March 2020

1 reference

LAD-1/variant syndrome is caused by mutations in FERMT3.

31 March 2020

1 reference

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

31 March 2020

1 reference

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

31 March 2020

1 reference

Kindlin-3 is essential for integrin activation and platelet aggregation

31 March 2020

1 reference

Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

31 March 2020

1 reference

A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.

31 March 2020

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Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

31 March 2020

1 reference

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

31 March 2020

1 reference

The ever-expanding spectrum of congenital muscular dystrophies

31 March 2020

1 reference

Mutations in the integrin alpha7 gene cause congenital myopathy

31 March 2020

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Absence of integrin alpha 7 causes a novel form of muscular dystrophy

31 March 2020

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Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice.

31 March 2020

1 reference

Role for the alpha7beta1 integrin in vascular development and integrity

31 March 2020

1 reference

Analysis of the mammalian talin2 gene TLN2.

31 March 2020

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Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

31 March 2020

1 reference

Immunolocalization of meta-vinculin in human smooth and cardiac muscles

31 March 2020

1 reference

Metavinculin mutations alter actin interaction in dilated cardiomyopathy.

31 March 2020

1 reference

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy

31 March 2020

1 reference

A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy

31 March 2020

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Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc

31 March 2020

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Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy

31 March 2020

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Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy

31 March 2020

1 reference

ZASP: a new Z-band alternatively spliced PDZ-motif protein

31 March 2020

1 reference

Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction

31 March 2020

1 reference

Mutations in ZASP define a novel form of muscular dystrophy in humans

31 March 2020

1 reference

ZASPopathy with childhood-onset distal myopathy.

31 March 2020

1 reference

Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy

31 March 2020

1 reference

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.

31 March 2020

1 reference

A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy

31 March 2020

1 reference

Current insights into the formation and breakdown of hemidesmosomes.

31 March 2020

1 reference

Overview of epidermolysis bullosa

31 March 2020

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Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.

31 March 2020

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Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival

31 March 2020

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Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice

31 March 2020

1 reference

Alopecia in epidermolysis bullosa

31 March 2020

1 reference

Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation

31 March 2020

1 reference

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.

31 March 2020

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Integrin α3 mutations with kidney, lung, and skin disease

31 March 2020

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Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome

31 March 2020

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α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane

31 March 2020

1 reference

The role of alpha3beta1 integrin in determining the supramolecular organization of laminin-5 in the extracellular matrix of keratinocytes

31 March 2020

1 reference

Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy

31 March 2020

1 reference

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

31 March 2020

1 reference

Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome.

31 March 2020

1 reference

Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes

31 March 2020

1 reference

Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes

31 March 2020

1 reference

Kindler syndrome pathogenesis and fermitin family homologue 1 (kindlin-1) function.

31 March 2020

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Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition

31 March 2020

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

31 March 2020

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Integrins in angiogenesis and lymphangiogenesis

31 March 2020

1 reference

Integrins in cancer: biological implications and therapeutic opportunities

31 March 2020

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The role of β3-integrins in tumor angiogenesis: context is everything

31 March 2020

1 reference

Integrin signalling adaptors: not only figurants in the cancer story

31 March 2020

1 reference

The role of focal adhesion kinase in tumor initiation and progression.

31 March 2020

1 reference

Focal adhesion kinase regulation of neovascularization

31 March 2020

1 reference

Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver

31 March 2020

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Oncogenic ILK, tumor suppression and all that JNK.

31 March 2020

1 reference

TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells

31 March 2020

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IL-8 increases integrin expression and cell motility in human chondrosarcoma cells

31 March 2020

1 reference

IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells

31 March 2020

1 reference

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells

31 March 2020

1 reference

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

31 March 2020

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Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma.

31 March 2020

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microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C.

31 March 2020

1 reference

miR-31 is a broad regulator of β1-integrin expression and function in cancer cells

31 March 2020

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miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.

31 March 2020

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Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice

31 March 2020

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Increased expression and phosphorylation of focal adhesion kinase correlates with dysfunction in the volume-overloaded human heart

31 March 2020

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Targeting Focal Adhesion Kinase With Small Interfering RNA Prevents and Reverses Load-Induced Cardiac Hypertrophy in Mice

31 March 2020

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Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats

31 March 2020

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ILK induces cardiomyogenesis in the human heart

31 March 2020

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FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex

31 March 2020

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Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy

31 March 2020

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Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice

31 March 2020

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Activation of RhoA in podocytes induces focal segmental glomerulosclerosis

31 March 2020

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Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

31 March 2020

1 reference

ILK, PINCH and parvin: the tIPP of integrin signalling

31 March 2020

1 reference

Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis.

31 March 2020

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Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus

31 March 2020

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Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis.

31 March 2020

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Increase of integrin-linked kinase activity in cultured podocytes upon stimulation with plasma from patients with recurrent FSGS.

31 March 2020

1 reference

Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation

31 March 2020

1 reference

Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes

31 March 2020

1 reference

Genetic background strongly influences the severity of glomerulosclerosis in mice

31 March 2020

1 reference

High affinity interactions of Coxsackievirus A9 with integrin alphavbeta3 (CD51/61) require the CYDMKTTC sequence of beta3, but do not require the RGD sequence of the CAV-9 VP1 protein.

31 March 2020

1 reference

Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformers

31 March 2020

1 reference

VP7 mediates the interaction of rotaviruses with integrin alphavbeta3 through a novel integrin-binding site

31 March 2020

1 reference

Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells

31 March 2020

1 reference

Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.

31 March 2020

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Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.

31 March 2020

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Integrin alphavbeta3 is a coreceptor for human cytomegalovirus

31 March 2020

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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

31 March 2020

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Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.

31 March 2020

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Cellular adhesion molecules as targets for bacterial infection

31 March 2020

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Integrin-mediated uptake of fibronectin-binding bacteria

31 March 2020

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Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction

31 March 2020

1 reference

Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation

31 March 2020

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Cortactin: a multifunctional regulator of cellular invasiveness

31 March 2020

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Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion kinase, Src and cortactin

31 March 2020

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Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells

31 March 2020

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Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.

31 March 2020

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Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.

31 March 2020

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Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.

31 March 2020

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CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells

31 March 2020

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Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling

31 March 2020

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Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation

31 March 2020

1 reference

Integrins as therapeutic targets.

31 March 2020

1 reference

Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis.

31 March 2020

1 reference

Efalizumab: a review of its use in the management of chronic moderate-to-severe plaque psoriasis

31 March 2020

1 reference

Contemporary use of glycoprotein IIb/IIIa inhibitors

31 March 2020

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Vedolizumab for the treatment of ulcerative colitis and Crohn's disease

31 March 2020

1 reference

Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies

31 March 2020

1 reference

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

31 March 2020

1 reference

Nanoscale architecture of integrin-based cell adhesions

31 March 2020

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Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

31 March 2020

1 reference

RNA sequencing: advances, challenges and opportunities

31 March 2020

1 reference

Genetic mapping in human disease

31 March 2020

1 reference

Decoding signalling networks by mass spectrometry-based proteomics

31 March 2020

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Precision proteomics: the case for high resolution and high mass accuracy

31 March 2020

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Quantitative, high-resolution proteomics for data-driven systems biology

31 March 2020

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Frontiers of microscopy-based research into cell-matrix adhesions

31 March 2020

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Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle

31 March 2020

1 reference

Reconstructing adhesion structures in tissues by cryo-electron tomography of vitrified frozen sections

31 March 2020

1 reference

Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration

31 March 2020

1 reference

Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase

31 March 2020

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12 December 2020

Vinculin knockout results in heart and brain defects during embryonic development.

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12 December 2020

Gene targeting yields a CD18-mutant mouse for study of inflammation.

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12 December 2020

Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.

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12 December 2020

Leukocyte adhesion deficiency-III in an African-American patient

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12 December 2020

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

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12 December 2020

A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex

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12 December 2020

Proteomic analysis of integrin adhesion complexes

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12 December 2020

Natalizumab for moderate to severe Crohn's disease in clinical practice: the Mayo Clinic Rochester experience

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12 December 2020

Identifiers

DOI

10.1038/NRM3769

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Dimensions Publication ID

30 August 2017

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