(Q38199772)

30 August 2017

title

The role of mitochondria in mTOR-regulated longevity (English)

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30 August 2017

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Yuehua Wei

1

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30 August 2017

Yan-Jie Zhang

series ordinal

2

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30 August 2017

Ying Cai

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3

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30 August 2017

Mang-Hua Xu

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4

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30 August 2017

language of work or name

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28 March 2014

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30 August 2017

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30 August 2017

volume

90

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30 August 2017

issue

1

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30 August 2017

page(s)

167-181

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

30 August 2017

cites work

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Autophagy is required for extension of yeast chronological life span by rapamycin

21 January 2018

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Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells

21 January 2018

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PGC-1alpha in aging and anti-aging interventions

21 January 2018

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Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat

21 January 2018

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

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Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2

21 January 2018

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

21 January 2018

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Mitochondria, oxidants, and aging

21 January 2018

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Mitochondrial free radical production and aging in mammals and birds

21 January 2018

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Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

21 January 2018

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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

21 January 2018

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The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

21 January 2018

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Two neurons mediate diet-restriction-induced longevity in C. elegans

21 January 2018

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Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk

21 January 2018

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

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21 January 2018

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Rapamycin and quasi-programmed aging: four years later

21 January 2018

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Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

21 January 2018

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The role of mitochondria in aging

21 January 2018

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Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

21 January 2018

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21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

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Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals

21 January 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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Mitochondrial signaling: the retrograde response

21 January 2018

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Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

21 January 2018

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Mitochondrial free radical generation, oxidative stress, and aging

21 January 2018

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

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Mitochondria: dynamic organelles in disease, aging, and development

21 January 2018

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LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

21 January 2018

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 January 2018

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Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells

21 January 2018

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Rapamycin-induced cytotoxic signal transduction pathway

21 January 2018

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Reactive oxygen species, cellular redox systems, and apoptosis

21 January 2018

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Complex I is the major site of mitochondrial superoxide production by paraquat

21 January 2018

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Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice

21 January 2018

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

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Lifespan regulation by evolutionarily conserved genes essential for viability

21 January 2018

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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

21 January 2018

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

21 January 2018

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FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

21 January 2018

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Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae

21 January 2018

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The cell-non-autonomous nature of electron transport chain-mediated longevity

21 January 2018

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Apoptosis: a review of programmed cell death

21 January 2018

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Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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Signal transduction by reactive oxygen species

21 January 2018

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Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

21 January 2018

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Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.

21 January 2018

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Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis.

21 January 2018

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In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

21 January 2018

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Superoxide dismutase 3, extracellular (SOD3) variants and lung function

21 January 2018

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

21 January 2018

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S6K1 deficiency protects against apoptosis in hepatocytes

21 January 2018

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The endosymbiont hypothesis revisited

21 January 2018

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Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage

21 January 2018

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Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

21 January 2018

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A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

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New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen

21 January 2018

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

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Aging: a theory based on free radical and radiation chemistry

21 January 2018

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ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

21 January 2018

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The mitochondrial UPR - protecting organelle protein homeostasis

21 January 2018

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The physiological role of mitophagy: new insights into phosphorylation events

21 January 2018

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Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

21 January 2018

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

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Mitonuclear protein imbalance as a conserved longevity mechanism

21 January 2018

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The use of transgenic and mutant mice to study oxygen free radical metabolism

21 January 2018

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Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity

21 January 2018

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Cellular senescence and organismal aging

21 January 2018

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

21 January 2018

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PINK1- and Parkin-mediated mitophagy at a glance

21 January 2018

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mTOR is a key modulator of ageing and age-related disease

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

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Tor directly controls the Atg1 kinase complex to regulate autophagy

21 January 2018

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Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles

21 January 2018

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Mitophagy in yeast occurs through a selective mechanism

21 January 2018

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A genomic screen for yeast mutants defective in selective mitochondria autophagy

21 January 2018

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TOR pathway: linking nutrient sensing to life span

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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A C. elegans mutant that lives twice as long as wild type

21 January 2018

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Mitophagy selectively degrades individual damaged mitochondria after photoirradiation

21 January 2018

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Selective degradation of mitochondria by mitophagy

21 January 2018

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Rapamycin increases oxidative stress response gene expression in adult stem cells

21 January 2018

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Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

21 January 2018

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Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

21 January 2018

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The genetics of caloric restriction in Caenorhabditis elegans

21 January 2018

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Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

21 January 2018

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Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span

21 January 2018

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

21 January 2018

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Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

21 January 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

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Metabolic control through the PGC-1 family of transcription coactivators

21 January 2018

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 January 2018

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A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function

21 January 2018

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Mitochondrial retrograde signaling

21 January 2018

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RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p

21 January 2018

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Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p

21 January 2018

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Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system

21 January 2018

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

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TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 January 2018

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Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.

21 January 2018

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Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases

21 January 2018

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VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

21 January 2018

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The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

21 January 2018

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Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

21 January 2018

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Role of reactive oxygen species in apoptosis: implications for cancer therapy.

21 January 2018

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Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

21 January 2018

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TOR and ageing: a complex pathway for a complex process.

21 January 2018

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mTORC1 directly phosphorylates and regulates human MAF1.

21 January 2018

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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS

21 January 2018

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Mitochondrial role in cell aging

21 January 2018

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The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

21 January 2018

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Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy

21 January 2018

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Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

21 January 2018

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Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

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Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

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Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling

21 January 2018

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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

21 January 2018

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Signaling the mitochondrial unfolded protein response

21 January 2018

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

21 January 2018

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Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

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A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice

21 January 2018

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Direct control of mitochondrial function by mTOR.

21 January 2018

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

21 January 2018

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Antioxidants prevent health-promoting effects of physical exercise in humans

21 January 2018

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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

21 January 2018

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Rapamycin sensitive ROS formation and Na(+)/H(+) exchanger activity in dendritic cells.

21 January 2018

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Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

21 January 2018

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Mitochondrial-nuclear communications

21 January 2018

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

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The mitochondrial free radical theory of aging: a critical view

21 January 2018

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Oxidative phosphorylation at the fin de siècle

21 January 2018

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Growing roles for the mTOR pathway

21 January 2018

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21 January 2018

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Mitochondrial signaling, TOR, and life span

21 January 2018

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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

21 January 2018

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Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1

21 January 2018

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Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

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ER stress and the unfolded protein response

21 January 2018

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 January 2018

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RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

21 January 2018

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Hydrogen peroxide production by liver mitochondria in different species.

21 January 2018

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Superoxide anion radical production in different animal species

21 January 2018

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Topology of superoxide production from different sites in the mitochondrial electron transport chain

21 January 2018

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

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Why have antioxidants failed in clinical trials?

21 January 2018

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FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies

21 January 2018

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Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism

21 January 2018

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Apoptosis: controlled demolition at the cellular level

21 January 2018

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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

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Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes

21 January 2018

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Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

21 January 2018

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Role of mitochondrial DNA in toxic responses to oxidative stress

21 January 2018

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

21 January 2018

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Superoxide dismutase is dispensable for normal animal lifespan

21 January 2018

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Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

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mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations

21 January 2018

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Caffeine extends yeast lifespan by targeting TORC1.

21 January 2018

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Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1.

21 January 2018

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Growth or longevity: the TOR's decision on lifespan regulation

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans

21 January 2018

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Reactive oxygen species-mediated control of mitochondrial biogenesis

21 January 2018

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

21 January 2018

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Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

21 January 2018

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A mitochondrial specific stress response in mammalian cells

21 January 2018

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A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

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4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

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Atg32 Is a tag for mitochondria degradation in yeast

21 January 2018

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Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BRV.12103

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30 August 2017

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