(Q38112382)

29 August 2017

Growth or longevity: the TOR's decision on lifespan regulation (English)

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29 August 2017

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Yuehua Wei

1

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29 August 2017

Yan-Jie Zhang

series ordinal

2

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29 August 2017

Ying Cai

series ordinal

3

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29 August 2017

language of work or name

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6 June 2013

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29 August 2017

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29 August 2017

14

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29 August 2017

4

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29 August 2017

353-363

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https://scigraph.springernature.com/pub.10.1007/s10522-013-9435-6

29 August 2017

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cites work

Autophagy is required for extension of yeast chronological life span by rapamycin

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https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

21 January 2018

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

21 January 2018

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Rapamycin passes the torch: a new generation of mTOR inhibitors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

The Vam6 GEF controls TORC1 by activating the EGO complex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

A longer and healthier life with TOR down-regulation: genetics and drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of peptide-chain elongation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Tor directly controls the Atg1 kinase complex to regulate autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

A C. elegans mutant that lives twice as long as wild type

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

On the programmed/non-programmed nature of ageing within the life history

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Rapamycin increases oxidative stress response gene expression in adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Stb3 plays a role in the glucose-induced transition from quiescence to growth in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Can autophagy promote longevity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

MAF1: a new target of mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

mTORC1 directly phosphorylates and regulates human MAF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Mitochondria, reactive oxygen species, and chronological aging: a message from yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Ribosome biogenesis: giant steps for a giant problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Increased molecular damage and heterogeneity as the basis of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Caffeine extends yeast lifespan by targeting TORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Nutritional control of cell growth via TOR signaling in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

The essential mechanisms of aging: Irreparable damage accumulation of biochemical side-reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Autophagy: molecular machinery for self-eating

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

Human longevity at the cost of reproductive success

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10522-013-9435-6

10.1007/S10522-013-9435-6

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

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1 reference