(Q38200490)

30 August 2017

4 references

6 August 2019

28 November 2019

15 December 2019

23 November 2020

Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues (English)

1 reference

pharmaceutical preparation

30 August 2017

1 reference

6 August 2019

1 reference

28 November 2019

1 reference

15 December 2019

positron emission tomography

1 reference

23 November 2020

0 references

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Thomas Wanek

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Martin Bauer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

Markus Alexander Zeitlinger

12 June 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

B Wulkersdorfer

1

1 reference

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12 June 2020

M Müller

5

1 reference

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12 June 2020

language of work or name

English

0 references

publication date

28 March 2014

1 reference

Clinical Pharmacology & Therapeutics

30 August 2017

1 August 2014

4 references

6 August 2019

28 November 2019

15 December 2019

23 November 2020

5 references

6 August 2019

28 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

23 November 2020

96

1 reference

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issue

2

1 reference

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12 June 2020

page(s)

206-213

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

12 June 2020

copyright license

4 references

6 August 2019

28 November 2019

15 December 2019

describes a project that uses

23 November 2020

positron emission tomography

1 reference

Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies

inferred from title

cites work

1 reference

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6 September 2017

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6 September 2017

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Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition

6 September 2017

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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

6 September 2017

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A perspective on efflux transport proteins in the liver

6 September 2017

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Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

6 September 2017

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A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier

6 September 2017

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PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET.

6 September 2017

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Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

6 September 2017

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Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up

6 September 2017

1 reference

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Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain

6 September 2017

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

6 September 2017

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Comparative requirements for exploratory clinical trials -- eIND, eCTA and microdosing

6 September 2017

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Approaches using molecular imaging technology — use of PET in clinical microdose studies

6 September 2017

1 reference

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Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux

6 September 2017

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P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide

6 September 2017

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Membrane transporters in drug development

6 September 2017

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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

6 September 2017

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Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate

6 September 2017

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Drug uptake systems in liver and kidney: a historic perspective

6 September 2017

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Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

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Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans

6 September 2017

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Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice

6 September 2017

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Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate

6 September 2017

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Drug interactions at the blood-brain barrier: fact or fantasy?

6 September 2017

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P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys

6 September 2017

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

6 September 2017

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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

6 September 2017

1 reference

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

6 September 2017

1 reference

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

6 September 2017

1 reference

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Methods to assess tissue-specific distribution and metabolism of drugs.

6 September 2017

1 reference

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Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

6 September 2017

1 reference

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The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

6 September 2017

1 reference

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Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development

6 September 2017

1 reference

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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

6 September 2017

1 reference

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The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

International Transporter Consortium commentary on clinically important transporter polymorphisms.

31 August 2018

1 reference

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Imaging in the study of membrane transporters

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Imaging of TKI-target interactions for personalized cancer therapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

PET imaging-based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Evaluation of limiting brain penetration related to P-glycoprotein and breast cancer resistance protein using [(11)C]GF120918 by PET in mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4153445

The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with [¹¹C]telmisartan

31 August 2018

1 reference

12 December 2020

Evaluation of breast cancer resistance protein function in hepatobiliary and renal excretion using PET with 11C-SC-62807

1 reference

12 December 2020

Drug distribution. The forgotten relative in clinical pharmacokinetics

1 reference

12 December 2020

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

1 reference

12 December 2020

Identifiers

DOI

10.1038/CLPT.2014.70

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

24682030

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24682030%20AND%20SRC:MED&resulttype=core&format=json