(Q27022933)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans (English)

1 reference

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28 February 2020

11

1 reference

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28 February 2020

Peter W. Swaan

13

1 reference

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28 February 2020

Aleksandra Galetin

16

1 reference

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28 February 2020

author name string

M J Zamek-Gliszczynski

1

2 references

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28 February 2020

C A Lee

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

A Poirier

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

J Bentz

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

X Chu

5

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

H Ellens

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

T Ishikawa

7

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

M Jamei

8

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

J C Kalvass

9

2 references

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28 February 2020

S Nagar

10

2 references

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28 February 2020

K Korzekwa

12

2 references

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28 February 2020

M E Taub

14

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

P Zhao

15

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

International Transporter Consortium

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

language of work or name

1 reference

25 February 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

28 February 2020

published in

2 references

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28 February 2020

volume

94

2 references

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28 February 2020

issue

1

2 references

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28 February 2020

page(s)

64-79

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

28 February 2020

cites work

1 reference

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Membrane transporters in drug development

21 March 2017

1 reference

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Review of P-gp inhibition data in recently approved new drug applications: utility of the proposed [I(1) ]/IC(50) and [I(2) ]/IC(50) criteria in the P-gp decision tree

7 April 2017

1 reference

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Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma

28 September 2017

1 reference

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Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Pharmaceutical excipients influence the function of human uptake transporting proteins.

28 September 2017

1 reference

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Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology

28 September 2017

1 reference

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In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

28 September 2017

1 reference

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

28 September 2017

1 reference

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Models to predict unbound intracellular drug concentrations in the presence of transporters

28 September 2017

1 reference

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Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Physiologically-based pharmacokinetics in drug development and regulatory science

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Population-based mechanistic prediction of oral drug absorption

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Prediction of intestinal first-pass drug metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Xenobiotic transporters: ascribing function from gene knockout and mutation studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

28 September 2017

1 reference

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Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

28 September 2017

1 reference

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The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics

28 September 2017

1 reference

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans

31 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Model analysis of the concentration-dependent permeability of P-gp substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Relationship between drug/metabolite exposure and impairment of excretory transport function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.45

Hepatic uptake of bromosulfophthalein-glutathione in perfused Eisai hyperbilirubinemic mutant rat liver: a multiple-indicator dilution study.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898877

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics

28 November 2018

1 reference

12 December 2020

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice

1 reference

12 December 2020

Highlights from the International Transporter Consortium second workshop

1 reference

12 December 2020

Metabolism and disposition of the antifolate LY231514 in mice and dogs

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

1 reference

12 December 2020

Use of transgenic and knockout mouse models to assess solute carrier transporter function

1 reference

12 December 2020

Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments

1 reference

12 December 2020

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

1 reference

12 December 2020

Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions

1 reference

12 December 2020

The impact of hepatic uptake on the pharmacokinetics of organic anions

1 reference

12 December 2020

Novel in vitro-in vivo extrapolation (IVIVE) method to predict hepatic organ clearance in rat

1 reference

12 December 2020

Identifiers

DOI

10.1038/CLPT.2013.45

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

2 references