(Q33516585)

27 July 2017

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data (English)

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27 July 2017

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Agnès Poirier

1

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27 July 2017

Anne-Christine Cascais

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2

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27 July 2017

Christoph Funk

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3

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27 July 2017

Thierry Lavé

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4

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27 July 2017

20 November 2009

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Journal of Pharmacokinetics and Pharmacodynamics

27 July 2017

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27 July 2017

36

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27 July 2017

585-611

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27 July 2017

6

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https://scigraph.springernature.com/pub.10.1007/s10928-009-9139-3

27 July 2017

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Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

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Membrane transport as a determinant of the hepatic elimination of drugs and metabolites

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Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

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12 December 2020

Protein binding in plasma of valsartan, a new angiotensin II receptor antagonist

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12 December 2020

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

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In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance

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Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor.

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12 December 2020

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

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Hepatocyte suspensions and cultures as tools in experimental carcinogenesis

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Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

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12 December 2020

In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.

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12 December 2020

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

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12 December 2020

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12 December 2020

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

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12 December 2020

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

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12 December 2020

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

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Extensive biliary excretion of the sulfasalazine analogue, susalimod, but different concentrations in the bile duct in various animal species correlating to species-specific hepatobiliary toxicity

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12 December 2020

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

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12 December 2020

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12 December 2020

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12 December 2020

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

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12 December 2020

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Valsartan. A review of its pharmacology and therapeutic use in essential hypertension

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12 December 2020

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The role of hepatic transporters in drug elimination

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12 December 2020

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12 December 2020

Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

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12 December 2020

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

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12 December 2020

Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose

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12 December 2020

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo

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12 December 2020

Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man

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12 December 2020

Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans

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12 December 2020

Hepatic bile entry into and transit pattern within the gallbladder lumen: a new quantitative cholescintigraphic technique for measurement of its concentration function.

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12 December 2020

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12 December 2020

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

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12 December 2020

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

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12 December 2020

Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man

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12 December 2020

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

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12 December 2020

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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12 December 2020

10.1007/S10928-009-9139-3

Identifiers

DOI

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Dimensions Publication ID

27 July 2017

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