(Q42282480)

English

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

scientific article published on 4 June 2012

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Aleksandra Galetin

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Karelle Ménochet

1

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3 February 2020

Kathryn E Kenworthy

2

1 reference

Europe PubMed Central

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3 February 2020

J Brian Houston

3

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3 February 2020

publication date

4 June 2012

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3 February 2020

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

40

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3 February 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1744-1756

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

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Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin

1 reference

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Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

1 reference

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Membrane transporters in drug development

1 reference

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Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data

1 reference

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26 October 2017

Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems.

1 reference

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26 October 2017

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

1 reference

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26 October 2017

Prediction of hepatic clearance in human from in vitro data for successful drug development

1 reference

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26 October 2017

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

1 reference

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26 October 2017

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

1 reference

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26 October 2017

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir

1 reference

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26 October 2017

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

1 reference

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26 October 2017

Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Evaluation of a pharmacokinetic interaction between valsartan and simvastatin in healthy subjects

1 reference

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26 October 2017

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Cyclosporine markedly raises the plasma concentrations of repaglinide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

1 reference

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26 October 2017

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

26 October 2017

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

1 reference

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26 October 2017

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

1 reference

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26 October 2017

Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling

1 reference

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26 October 2017

Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations

1 reference

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26 October 2017

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

1 reference

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29 May 2018

A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

1 reference

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17 August 2018

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

1 reference

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17 August 2018

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

1 reference

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17 August 2018

Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics

1 reference

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17 August 2018

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

1 reference

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17 August 2018

Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422540

17 August 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

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17 August 2018

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

1 reference

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1 reference

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17 August 2018

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1 reference

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17 August 2018

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17 August 2018

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1 reference

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30 September 2018

In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of hepatic uptake on the pharmacokinetics of organic anions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, metabolism, and excretion of intravenously and orally administered [14C]telmisartan in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22665271

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.112.046193

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22665271%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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