(Q82100906)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011931%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Novel in vitro-in vivo extrapolation (IVIVE) method to predict hepatic organ clearance in rat (English)

1 reference

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14 January 2020

author name string

Ken-ichi Umehara

series ordinal

1

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14 January 2020

Gian Camenisch

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011931%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

publication date

20 October 2011

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14 January 2020

published in

Pharmaceutical Research

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14 January 2020

volume

29

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14 January 2020

issue

2

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14 January 2020

page(s)

603-617

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Metabolic clearance of furosemide in the rat

14 January 2020

cites work

1 reference

12 December 2020

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

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Distribution of quinidine in rats with carbon tetrachloride-intoxicated hepatic disease

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Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.

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Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models

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Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose

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12 December 2020

Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

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12 December 2020

Dose-dependent pharmacokinetics of cyclosporin A in rats: events in tissues.

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12 December 2020

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

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Biliary excretion and enterohepatic circulation of two beta-adrenergic blocking drugs, exaprolol and propranolol in rats

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12 December 2020

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

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12 December 2020

Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes.

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12 December 2020

Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes

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12 December 2020

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

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12 December 2020

In vitro-in vivo extrapolation of hepatic clearance involving active uptake: theoretical and experimental aspects

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12 December 2020

Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren

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12 December 2020

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

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12 December 2020

The effect of infliximab on hepatic cytochrome P450 and pharmacokinetics of verapamil in rats with pre-adjuvant arthritis: a drug-disease and drug-drug interaction

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12 December 2020

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration

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12 December 2020

Pharmacokinetic interaction between efavirenz and ketoconazole in rats

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12 December 2020

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

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12 December 2020

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

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12 December 2020

Molecular aspects of hepatobiliary transport

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12 December 2020

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

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12 December 2020

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

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12 December 2020

Renal tubular transport of penicillin G and carbenicillin in the rat

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12 December 2020

Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes.

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12 December 2020

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

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12 December 2020

Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism

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12 December 2020

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

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12 December 2020

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

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12 December 2020

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

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12 December 2020

In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

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12 December 2020

Tissue distribution, disposition, and metabolism of cyclosporine in rats

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12 December 2020

The disposition and pharmacokinetics of ketoconazole in the rat

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12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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12 December 2020

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

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12 December 2020

Comparison of disposition parameters of quinidine and quinine in the rat

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12 December 2020

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

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12 December 2020

Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

1 reference

12 December 2020

Uptake of sulfate conjugates by isolated rat hepatocytes.

1 reference

12 December 2020

Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A

1 reference

12 December 2020

Pharmacokinetics of digoxin in the rat

1 reference

12 December 2020

Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes

1 reference

12 December 2020

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

1 reference

12 December 2020

Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes

1 reference

12 December 2020

Impact of OATP transporters on pharmacokinetics

1 reference

12 December 2020

Clearance approaches in pharmacology.

1 reference

12 December 2020

Metabolism and excretion of atorvastatin in rats and dogs

1 reference

12 December 2020

Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter

1 reference

12 December 2020

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

1 reference

12 December 2020

Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomes

1 reference

12 December 2020

Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resista

1 reference

12 December 2020

Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

1 reference

12 December 2020

The effect of age on digoxin pharmacokinetics in Fischer-344 rats

1 reference

12 December 2020

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

1 reference

12 December 2020

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo

1 reference

12 December 2020

Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide

1 reference

12 December 2020

Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans

1 reference

12 December 2020

Correlation between in vivo and in vitro hepatic uptake of metabolic inhibitors of cytochrome P-450 in rats

1 reference

12 December 2020

Evaluating barriers to bioavailability in vivo: validation of a technique for separately assessing gastrointestinal absorption and hepatic extraction

1 reference

12 December 2020

Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters

1 reference

12 December 2020

Influence of renal failure on ciprofloxacin pharmacokinetics in rats.

1 reference

12 December 2020

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of verapamil after intravenous and oral administration of racemic verapamil in a rat model

1 reference

12 December 2020

Effect of the anticoagulant ethylenediamine tetra-acetic acid (EDTA) on the estimation of pharmacokinetic parameters: A case study with tigecycline and ciprofloxacin

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

1 reference

12 December 2020

Kinetic analysis about the bidirectional transport of 1-anilino-8-naphthalene sulfonate (ANS) by isolated rat hepatocytes

1 reference

12 December 2020

10.1007/S11095-011-0607-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011931%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference