(Q38203783)

30 August 2017

title

Mechanisms regulating skin immunity and inflammation (English)

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30 August 2017

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Manolis Pasparakis

1

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author name string

Ingo Haase

series ordinal

2

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30 August 2017

Frank O Nestle

series ordinal

3

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30 August 2017

publication date

11 April 2014

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Nature Reviews Immunology

30 August 2017

published in

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30 August 2017

volume

14

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30 August 2017

issue

5

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30 August 2017

page(s)

289-301

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Skin immune sentinels in health and disease

30 August 2017

cites work

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The multitasking organ: recent insights into skin immune function

31 March 2020

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Langerhans cells arise from monocytes in vivo

31 March 2020

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Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages

31 March 2020

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Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia

31 March 2020

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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

31 March 2020

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Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.

31 March 2020

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Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin

31 March 2020

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Compensatory dendritic cell development mediated by BATF-IRF interactions

31 March 2020

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Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage.

31 March 2020

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Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses

31 March 2020

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Langerhans cells cross-present antigen derived from skin

31 March 2020

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Antigen presentation by Langerhans cells

31 March 2020

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Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells

31 March 2020

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CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity

31 March 2020

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What on "irf" is this gene 4? Irf4 transcription-factor-dependent dendritic cells are required for T helper 2 cell responses in murine skin

31 March 2020

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Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice

31 March 2020

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TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection

31 March 2020

1 reference

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

31 March 2020

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Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

31 March 2020

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Th17 cells and activated dendritic cells are increased in vitiligo lesions

31 March 2020

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Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells

31 March 2020

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Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.

31 March 2020

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Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells

31 March 2020

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Human 6-sulfo LacNAc (slan) dendritic cells are a major population of dermal dendritic cells in steady state and inflammation

31 March 2020

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Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

31 March 2020

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Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells

31 March 2020

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Harnessing dendritic cells in inflammatory skin diseases.

31 March 2020

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Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema

31 March 2020

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Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

31 March 2020

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Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

31 March 2020

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The innate immune system in SLE: type I interferons and dendritic cells

31 March 2020

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Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

31 March 2020

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TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis

31 March 2020

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CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues

31 March 2020

1 reference

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

31 March 2020

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

31 March 2020

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Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages

31 March 2020

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Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes

31 March 2020

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Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells

31 March 2020

1 reference

Exploring the full spectrum of macrophage activation

31 March 2020

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A subpopulation of CD163-positive macrophages is classically activated in psoriasis

31 March 2020

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Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma

31 March 2020

1 reference

Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation

31 March 2020

1 reference

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

31 March 2020

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A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses

31 March 2020

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Macrophage plasticity and polarization in tissue repair and remodelling

31 March 2020

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Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.

31 March 2020

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Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

31 March 2020

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Infection regulates pro-resolving mediators that lower antibiotic requirements

31 March 2020

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Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

31 March 2020

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Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

31 March 2020

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Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein

31 March 2020

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Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis

31 March 2020

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Skin-associated lymphoid tissues (SALT): origins and functions

31 March 2020

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Immune surveillance in the skin: mechanisms and clinical consequences

31 March 2020

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Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha

31 March 2020

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The pathogenic role of tissue-resident immune cells in psoriasis.

31 March 2020

1 reference

Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

31 March 2020

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The vast majority of CLA+ T cells are resident in normal skin.

31 March 2020

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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

31 March 2020

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Dynamic T cell migration program provides resident memory within intestinal epithelium

31 March 2020

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Different patterns of peripheral migration by memory CD4+ and CD8+ T cells.

31 March 2020

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Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.

31 March 2020

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A vaccine strategy that protects against genital herpes by establishing local memory T cells

31 March 2020

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Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity

31 March 2020

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Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity

31 March 2020

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Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection

31 March 2020

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Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.

31 March 2020

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Response to self antigen imprints regulatory memory in tissues

31 March 2020

1 reference

Six-of-the-best: unique contributions of γδ T cells to immunology

31 March 2020

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Skint-1 is a highly specific, unique selecting component for epidermal T cells

31 March 2020

1 reference

Promoting angiogenesis within the tumor microenvironment: the secret life of murine lymphoid IL-17-producing gammadelta T cells

31 March 2020

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Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells

31 March 2020

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Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis

31 March 2020

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Hiding under the skin: Interleukin-17-producing γδ T cells go under the skin?

31 March 2020

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Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation

31 March 2020

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Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

31 March 2020

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Deficiency in IL-17-committed Vγ4(+) γδ T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis

31 March 2020

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IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice

31 March 2020

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Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.

31 March 2020

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CCR6 is required for epidermal trafficking of γδ-T cells in an IL-23-induced model of psoriasiform dermatitis

31 March 2020

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Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk

31 March 2020

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Reduction of CD18 promotes expansion of inflammatory γδ T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis

31 March 2020

1 reference

Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis

31 March 2020

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Cross-talk between intraepithelial γδ T cells and epithelial cells

31 March 2020

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The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

31 March 2020

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Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

31 March 2020

1 reference

Innate lymphoid cells--a proposal for uniform nomenclature

31 March 2020

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Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis

31 March 2020

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Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

31 March 2020

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A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

31 March 2020

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Differential expression of phosphorylated NF-kappaB/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanercept

31 March 2020

1 reference

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

31 March 2020

1 reference

Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis

31 March 2020

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Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease

31 March 2020

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Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

31 March 2020

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TNFalpha shedding and epidermal inflammation are controlled by Jun proteins

31 March 2020

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Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice

31 March 2020

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Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos

31 March 2020

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Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines

31 March 2020

1 reference

Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial

31 March 2020

1 reference

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

31 March 2020

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Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition

31 March 2020

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Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

31 March 2020

1 reference

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

31 March 2020

1 reference

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

31 March 2020

1 reference

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

31 March 2020

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

31 March 2020

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Protective roles for caspase-8 and cFLIP in adult homeostasis.

31 March 2020

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cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis

31 March 2020

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Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

31 March 2020

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TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

31 March 2020

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TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

31 March 2020

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Linear ubiquitination prevents inflammation and regulates immune signalling

31 March 2020

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

31 March 2020

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

31 March 2020

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Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

31 March 2020

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Epithelial NEMO links innate immunity to chronic intestinal inflammation

31 March 2020

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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

31 March 2020

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Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8.

31 March 2020

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c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

31 March 2020

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Manipulation of kinase signaling by bacterial pathogens

31 March 2020

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Inhibitors of NF-kappaB signaling: 785 and counting

31 March 2020

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Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

31 March 2020

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Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

31 March 2020

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A type III effector antagonizes death receptor signalling during bacterial gut infection

31 March 2020

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Topographic diversity of fungal and bacterial communities in human skin

31 March 2020

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Topographical and temporal diversity of the human skin microbiome

31 March 2020

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Epithelial antimicrobial defence of the skin and intestine

31 March 2020

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Immune mediated shaping of microflora community composition depends on barrier site

31 March 2020

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Compartmentalized control of skin immunity by resident commensals

31 March 2020

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31 March 2020

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Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus

31 March 2020

1 reference

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

31 March 2020

1 reference

Integrative biology approach identifies cytokine targeting strategies for psoriasis

31 March 2020

1 reference

Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity

31 March 2020

1 reference

12 December 2020

Specialized role of migratory dendritic cells in peripheral tolerance induction

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12 December 2020

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets

1 reference

12 December 2020

TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3646

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30 August 2017

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