(Q38204542)

31 August 2017

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome (English)

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metabolic dysfunction–associated steatotic liver disease

31 August 2017

1 reference

0 references

1 reference

non-alcoholic fatty liver

inferred from title

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1 reference

1

Hannele Yki-Järvinen

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31 August 2017

7 April 2014

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The Lancet: Diabetes & Endocrinology

31 August 2017

1 reference

31 August 2017

2

1 reference

31 August 2017

11

1 reference

31 August 2017

901-910

1 reference

The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation

31 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internat

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Liver fat in the metabolic syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma: fertile soil

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Obesity, insulin resistance, NASH and hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: results from the Rotterdam study

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Increased risk of type 2 diabetes in subjects with both elevated liver enzymes and ultrasonographically diagnosed nonalcoholic fatty liver disease: a 4-year longitudinal study

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-year prospective cohort study

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Metabolic syndrome and gallstone disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Cholecystectomy and NAFLD: does gallbladder removal have metabolic consequences?

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Pathophysiology of human visceral obesity: an update

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Development of new fatty liver, or resolution of existing fatty liver, over five years of follow-up, and risk of incident hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population: the Zhejiang Zhenhai Study.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The effect of lifestyle changes in non-alcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The impact of bariatric surgery on nonalcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Hypoxia and adipose tissue function and dysfunction in obesity.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the Dallas Heart Study

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Adiponectin: mechanistic insights and clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Visceral fat and insulin resistance--causative or correlative?

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Sweetened beverage consumption and risk of coronary heart disease in women

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Carbohydrate intake and nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Increased Insulin Sensitivity and Insulin Binding to Monocytes after Physical Training

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Exercise and the liver: implications for therapy in fatty liver disorders

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Heritability of nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Geographic variations of the International Diabetes Federation and the National Cholesterol Education Program-Adult Treatment Panel III definitions of the metabolic syndrome in nondiabetic subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Fibrosis and adipose tissue dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The genetics of NAFLD.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

A common variant in the peroxisome proliferator–activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

A feed-forward loop amplifies nutritional regulation of PNPLA3

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

Decrease in hepatic very-low-density lipoprotein-triglyceride secretion after weight loss is inversely associated with changes in circulating leptin

1 reference

https://api.crossref.org/works/10.1016%2FS2213-8587%2814%2970032-4

7 January 2021

10.1016/S2213-8587(14)70032-4

Identifiers

DOI

1 reference

31 August 2017

1 reference

PubMed ID

24731669