(Q38218540)

31 August 2017

Biotransformation and bioactivation reactions of alicyclic amines in drug molecules (English)

1 reference

31 August 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Jayaprakasam Bolleddula

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kevin DeMent

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Philip Worboys

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Patrick J Brassil

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

David L Bourdet

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

9 June 2014

1 reference

31 August 2017

Drug Metabolism Reviews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

379-419

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists

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Antidepressant-induced liver injury

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

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Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem

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Psychiatric Sequelae of Phencyclidine Abuse

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cis- and trans-1,2-diphenylaziridines: induction of xenobiotic-metabolizing enzymes in rat liver and mutagenicity in Salmonella typhimurium

21 January 2018

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Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders

21 January 2018

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Metabolism of aziridines and the mechanism of their cytotoxicity

21 January 2018

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2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor

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21 January 2018

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Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition

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Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma

21 January 2018

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Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.

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21 January 2018

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21 January 2018

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Pharmacokinetics, disposition, and metabolism of bicifadine in humans

21 January 2018

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Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase

21 January 2018

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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

21 January 2018

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Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products

21 January 2018

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Benzodiazepine metabolism: an analytical perspective

21 January 2018

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The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism

21 January 2018

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Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship

21 January 2018

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Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man.

21 January 2018

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In vitro metabolism of gefitinib in human liver microsomes

21 January 2018

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Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

21 January 2018

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Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats

21 January 2018

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Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia

21 January 2018

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Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent

21 January 2018

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Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC.

21 January 2018

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Recent developments in the field of antitumour anthracyclines

21 January 2018

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Pharmacokinetics, disposition, and metabolism of bicifadine in the mouse, rat, and monkey

21 January 2018

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Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans

21 January 2018

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Metabolic oxidation of nicotine to chemically reactive intermediates

21 January 2018

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Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia

21 January 2018

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Bioactivation of tamoxifen by recombinant human cytochrome p450 enzymes

21 January 2018

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Drug-metabolizing enzymes in the skin of man, rat, and pig.

21 January 2018

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Inhibition of P450 cytochromes by reactive intermediates.

21 January 2018

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Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide

21 January 2018

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Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development.

21 January 2018

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In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery

21 January 2018

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Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.

21 January 2018

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Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far?

21 January 2018

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Update on the clinical efficacy and side effects of clozapine

21 January 2018

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Trazodone and intrahepatic cholestasis

21 January 2018

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Liver and lung microsomal metabolism of the tobacco alkaloid beta-nicotyrine

21 January 2018

1 reference

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Clinical pharmacology of phencyclidine toxicity

21 January 2018

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Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

21 January 2018

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Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog.

21 January 2018

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Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein

21 January 2018

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

21 January 2018

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Comparative cytotoxicities of various morpholinyl anthracyclines.

21 January 2018

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Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2014.924962

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

21 January 2018

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Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design

21 January 2018

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Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity

21 January 2018

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Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

21 January 2018

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Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine

21 January 2018

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Idiosyncratic drug reactions: past, present, and future

21 January 2018

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Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes

21 January 2018

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Differences in the metabolism of epicainide in rats and man.

21 January 2018

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Metabolic studies on haloperidol and its tetrahydropyridine analog in C57BL/6 mice

21 January 2018

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Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor

21 January 2018

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The biotransformation of nitrogen containing xenobiotics to lactams.

21 January 2018

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Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine

21 January 2018

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Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

21 January 2018

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21 January 2018

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Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent in

21 January 2018

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Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.

21 January 2018

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A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

Biotransformation and in vitro assessment of metabolism-associated drug-drug interaction for CRx-102, a novel combination drug candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

Degradation of Benzylpenicillin at pH 7.5 to D-Benzylpenicilloic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.924962

10.3109/03602532.2014.924962

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24909234%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference