(Q38222570)

31 August 2017

title

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms (English)

1 reference

14-alpha sterol demethylase

31 August 2017

main subject

Aspergillus fumigatus

0 references

1 reference

GeneDB

antifungal drug resistance

6 February 2019

1 reference

Cheshta Sharma

2

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Ferry Hagen

object named as

Ferry Hagen

series ordinal

3

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Jacques F. Meis

object named as

Jacques F Meis

series ordinal

4

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author name string

Anuradha Chowdhary

series ordinal

1

1 reference

31 August 2017

publication date

1 January 2014

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31 August 2017

number of pages

15

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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31 August 2017

volume

9

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31 August 2017

issue

5

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31 August 2017

page(s)

697-711

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Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults

31 August 2017

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Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Aspergillus species to the triazoles

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Development of novel PCR assays to detect azole resistance-mediating mutations of the Aspergillus fumigatus cyp51A gene in primary clinical samples from neutropenic patients.

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21 January 2018

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A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

21 January 2018

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High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.

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Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.

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21 January 2018

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21 January 2018

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21 January 2018

1 reference

Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India

21 January 2018

1 reference

Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

21 January 2018

1 reference

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

21 January 2018

1 reference

Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma

21 January 2018

1 reference

Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery.

21 January 2018

1 reference

Novel mixed-format real-time PCR assay to detect mutations conferring resistance to triazoles in Aspergillus fumigatus and prevalence of multi-triazole resistance among clinical isolates in the Netherlands.

21 January 2018

1 reference

Evidence for genetic differentiation and variable recombination rates among Dutch populations of the opportunistic human pathogen Aspergillus fumigatus.

21 January 2018

1 reference

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance

21 January 2018

1 reference

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

21 January 2018

1 reference

First reported case of azole-resistant aspergillus fumigatus due to the TR/L98H mutation in Germany

21 January 2018

1 reference

Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter

21 January 2018

1 reference

Multi-azole resistance in Aspergillus fumigatus

21 January 2018

1 reference

Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma

21 January 2018

1 reference

Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis

21 January 2018

1 reference

Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling.

21 January 2018

1 reference

Antifungal agents: mechanisms of action

21 January 2018

1 reference

Clinical pharmacology of antifungal compounds

21 January 2018

1 reference

Current options in antifungal pharmacotherapy.

21 January 2018

1 reference

P450 inhibitors of use in medical treatment: focus on mechanisms of action

21 January 2018

1 reference

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

21 January 2018

1 reference

Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals

21 January 2018

1 reference

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

21 January 2018

1 reference

Emergence of azole-resistant aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health

21 January 2018

1 reference

Azole resistance in Aspergillus fumigatus: a growing public health concern.

21 January 2018

1 reference

Efflux in fungi: la pièce de résistance

21 January 2018

1 reference

Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus

21 January 2018

1 reference

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

21 January 2018

1 reference

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

21 January 2018

1 reference

Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity

21 January 2018

1 reference

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates

21 January 2018

1 reference

Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors

21 January 2018

1 reference

SREBPs: sterol-regulated transcription factors

21 January 2018

1 reference

Regulation of sterol synthesis in eukaryotes.

21 January 2018

1 reference

A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus

21 January 2018

1 reference

Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence

21 January 2018

1 reference

SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).

21 January 2018

1 reference

SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus

21 January 2018

1 reference

Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing

21 January 2018

1 reference

Triazole fungicides and the selection of resistance to medical triazoles in the opportunistic mould Aspergillus fumigatus.

21 January 2018

1 reference

Assessment of selection and resistance risk for demethylation inhibitor fungicides in Aspergillus fumigatus in agriculture and medicine: a critical review

21 January 2018

1 reference

Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus

21 January 2018

1 reference

Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis

21 January 2018

1 reference

Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America

21 January 2018

1 reference

Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis

21 January 2018

1 reference

Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis

21 January 2018

1 reference

In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus.

21 January 2018

1 reference

Aspergillus species intrinsically resistant to antifungal agents.

21 January 2018

1 reference

Update on Antifungal Resistance and its Clinical Impact

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.14.27

1 reference

31 August 2017

1 reference