(Q38226333)

31 August 2017

title

Bone morphogenetic proteins as regulators of iron metabolism (English)

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31 August 2017

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Nermi L Parrow

1

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31 August 2017

Robert E Fleming

series ordinal

2

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31 August 2017

language of work or name

English

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publication date

6 June 2014

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Annual Review of Nutrition

31 August 2017

published in

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31 August 2017

volume

34

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31 August 2017

page(s)

77-94

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Inherited disorders of iron metabolism

31 August 2017

cites work

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12 December 2020

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

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12 December 2020

The distal location of the iron responsive region of the hepcidin promoter.

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12 December 2020

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

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BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

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12 December 2020

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice

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Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

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BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

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12 December 2020

Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation

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12 December 2020

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

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12 December 2020

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

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12 December 2020

Hepcidin and disorders of iron metabolism

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12 December 2020

Iron-refractory iron deficiency anemia

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Smad transcription factors

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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

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The logic of TGFbeta signaling.

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12 December 2020

Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system

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Regulation of iron acquisition and storage: consequences for iron-linked disorders

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12 December 2020

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

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12 December 2020

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

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Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators

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BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.

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12 December 2020

Hepcidin and iron regulation, 10 years later

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12 December 2020

Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway

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The long history of iron in the Universe and in health and disease

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

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12 December 2020

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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12 December 2020

Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis

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12 December 2020

Things that go BMP in the liver: bone morphogenetic protein 6 and the control of body iron homeostasis

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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

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Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

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12 December 2020

BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos

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12 December 2020

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression

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12 December 2020

Iron-Induced Expression of Bone Morphogenic Protein 6 in Intestinal Cells Is the Main Regulator of Hepatic Hepcidin Expression In Vivo

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12 December 2020

Role of matriptase-2 (TMPRSS6) in iron metabolism

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12 December 2020

Twisted gastrulation can function as a BMP antagonist.

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12 December 2020

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

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12 December 2020

Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1

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12 December 2020

Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression

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12 December 2020

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

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12 December 2020

Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

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The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

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12 December 2020

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

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New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia

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Bmp6 expression can be regulated independently of liver iron in mice

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12 December 2020

Hepatic iron overload and hepatocellular carcinoma

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12 December 2020

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

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Two to tango: regulation of Mammalian iron metabolism

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12 December 2020

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

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12 December 2020

Knockout mouse models of iron homeostasis

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12 December 2020

Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis

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12 December 2020

Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone.

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12 December 2020

Iron regulation and erythropoiesis

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12 December 2020

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

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12 December 2020

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

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12 December 2020

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe

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12 December 2020

Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice

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12 December 2020

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

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12 December 2020

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12 December 2020

A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis

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12 December 2020

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

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12 December 2020

Liver and serum iron: discrete regulators of hepatic hepcidin expression

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12 December 2020

Mammalian iron transport.

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12 December 2020

BMP6 orchestrates iron metabolism.

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12 December 2020

Bone morphogenetic protein

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12 December 2020

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

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12 December 2020

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

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12 December 2020

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

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12 December 2020

The molecular pathogenesis of hereditary hemochromatosis

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12 December 2020

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

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12 December 2020

The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation

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12 December 2020

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

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12 December 2020

Long-range action of Nodal requires interaction with GDF1.

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12 December 2020

Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism

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12 December 2020

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

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12 December 2020

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.

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12 December 2020

10.1146/ANNUREV-NUTR-071813-105646

Identifiers

DOI

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31 August 2017

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