(Q38237619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Targeting PI3-kinase (PI3K), AKT and mTOR axis in lymphoma (English)

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12 March 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Robert A Baiocchi

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

English

0 references

publication date

6 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Haematology

12 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

167

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12 March 2020

issue

1

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12 March 2020

page(s)

19-32

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

12 March 2020

cites work

1 reference

Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study

21 January 2018

1 reference

MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen

21 January 2018

1 reference

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

21 January 2018

1 reference

The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways.

21 January 2018

1 reference

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma

21 January 2018

1 reference

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

1 reference

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

21 January 2018

1 reference

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma

21 January 2018

1 reference

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

21 January 2018

1 reference

PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma

21 January 2018

1 reference

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

21 January 2018

1 reference

Akt signalling in health and disease.

21 January 2018

1 reference

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

21 January 2018

1 reference

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

1 reference

PTEN hamartoma tumor syndrome: an overview

21 January 2018

1 reference

Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer

21 January 2018

1 reference

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

21 January 2018

1 reference

P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse

21 January 2018

1 reference

The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells

21 January 2018

1 reference

A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL).

21 January 2018

1 reference

The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells

21 January 2018

1 reference

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection

21 January 2018

1 reference

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

21 January 2018

1 reference

Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals

21 January 2018

1 reference

A mosaic activating mutation in AKT1 associated with the Proteus syndrome

21 January 2018

1 reference

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

21 January 2018

1 reference

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

1 reference

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

21 January 2018

1 reference

The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival

21 January 2018

1 reference

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

21 January 2018

1 reference

PI3K in lymphocyte development, differentiation and activation

21 January 2018

1 reference

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

21 January 2018

1 reference

Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma

21 January 2018

1 reference

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

21 January 2018

1 reference

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

21 January 2018

1 reference

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

21 January 2018

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

1 reference

Making new contacts: the mTOR network in metabolism and signalling crosstalk

21 January 2018

1 reference

Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex

21 January 2018

1 reference

Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium

21 January 2018

1 reference

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 January 2018

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Immunoregulatory functions of mTOR inhibition.

21 January 2018

1 reference

BRAF mutations in hairy-cell leukemia

21 January 2018

1 reference

Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85alpha subunit of phosphoinositide-3 kinase.

21 January 2018

1 reference

PI3K signalling: the path to discovery and understanding.

21 January 2018

1 reference

PAK1 mediates resistance to PI3K inhibition in lymphomas.

21 January 2018

1 reference

Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab.

21 January 2018

1 reference

Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

21 January 2018

1 reference

A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma

21 January 2018

1 reference

The B-cell receptor signaling pathway as a therapeutic target in CLL.

21 January 2018

1 reference

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

21 January 2018

1 reference

Genetic heterogeneity of diffuse large B-cell lymphoma

21 January 2018

1 reference

Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BJH.13065

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25100567%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference