(Q34380652)

English

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

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28 February 2020

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency (English)

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28 February 2020

cellular senescence

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Carrie L. Lucas

1

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28 February 2020

Julie E. Niemela

4

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28 February 2020

Elissa K. Deenick

5

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28 February 2020

Matthew Biancalana

10

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28 February 2020

12

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28 February 2020

Joao B. Oliveira

24

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28 February 2020

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28 February 2020

28

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Gulbu Uzel

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28 February 2020

Stefania Pittaluga

21

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Stefania Pittaluga

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28 February 2020

14

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V Koneti Rao

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28 February 2020

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Hye Sun Kuehn

2

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28 February 2020

Fang Zhao

3

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28 February 2020

Umaimainthan Palendira

6

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28 February 2020

Danielle T Avery

7

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28 February 2020

Leen Moens

8

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28 February 2020

Jennifer L Cannons

9

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28 February 2020

Jennifer Stoddard

11

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28 February 2020

David M Frucht

13

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28 February 2020

T Prescott Atkinson

15

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28 February 2020

Anahita Agharahimi

16

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28 February 2020

Ashleigh A Hussey

17

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28 February 2020

Les R Folio

18

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28 February 2020

Kenneth N Olivier

19

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28 February 2020

Thomas A Fleisher

20

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28 February 2020

Steven M Holland

22

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28 February 2020

Jeffrey I Cohen

23

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28 February 2020

Pamela L Schwartzberg

26

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28 February 2020

Michael J Lenardo

27

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28 February 2020

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28 October 2013

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28 February 2020

Nature Immunology

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28 February 2020

15

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28 February 2020

1

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28 February 2020

88-97

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28 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4209962/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

1 reference

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6 July 2018

The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

1 reference

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6 July 2018

Role of PI3K/Akt signaling in memory CD8 T cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

mTOR and metabolic pathways in T cell quiescence and functional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

mTOR, linking metabolism and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Transcriptional control of effector and memory CD8+ T cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

PI3K-PKB/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Signal integration by Akt regulates CD8 T cell effector and memory differentiation.

1 reference

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6 July 2018

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

1 reference

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6 July 2018

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Activation of mTORC2 by association with the ribosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants

1 reference

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6 July 2018

PI3 kinase signals BCR-dependent mature B cell survival

1 reference

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6 July 2018

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

mTOR regulates memory CD8 T-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Class I PI3K in oncogenic cellular transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Structural comparisons of class I phosphoinositide 3-kinases

1 reference

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6 July 2018

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

1 reference

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6 July 2018

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

1 reference

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6 July 2018

Current development of mTOR inhibitors as anticancer agents

1 reference

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6 July 2018

Oncogenic PI3K deregulates transcription and translation

1 reference

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6 July 2018

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6 July 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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Generation and maintenance of immunological memory

1 reference

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6 July 2018

PI3K in lymphocyte development, differentiation and activation

1 reference

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6 July 2018

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

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6 July 2018

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

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6 July 2018

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6 July 2018

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

1 reference

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6 July 2018

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209962

6 July 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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6 July 2018

Epidemiology of EBV and Hodgkin's lymphoma

1 reference

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6 July 2018

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

1 reference

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27 October 2018

Oncogenic signaling of class I PI3K isoforms

1 reference

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27 October 2018

Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling

1 reference

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27 October 2018

Identification of variations in the human phosphoinositide 3-kinase p110delta gene in children with primary B-cell immunodeficiency of unknown aetiology

1 reference

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27 October 2018

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

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A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

1 reference

https://pubmed.ncbi.nlm.nih.gov/24165795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

1 reference

https://api.crossref.org/works/10.1038%2FNI.2771

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/NI.2771

1 reference

Europe PubMed Central

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28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165795%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165795%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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