(Q38238609)

31 August 2017

PI3K/Akt-mediated regulation of p53 in cancer (English)

1 reference

31 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Eric O'Neill

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

1 August 2014

1 reference

Biochemical Society Transactions

31 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

798-803

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

Hallmarks of Cancer: The Next Generation

2 June 2020

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

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Mutant p53 drives invasion by promoting integrin recycling

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Phosphoinositide kinases

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PI3K-Akt pathway: its functions and alterations in human cancer

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Apoptosis - the p53 network

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The p53-Bcl-2 connection

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

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Divorcing ARF and p53: an unsettled case

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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INK4a/ARF: a multifunctional tumor suppressor locus

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Blinded by the Light: The Growing Complexity of p53

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Multiple stress signals activate mutant p53 in vivo

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Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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Elevated PI3K signaling drives multiple breast cancer subtypes

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Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

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Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.

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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

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Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability

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DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer

21 January 2018

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Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

21 January 2018

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Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

21 January 2018

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

21 January 2018

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The role of mutant p53 in human cancer

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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

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Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.

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Akt, FoxO and regulation of apoptosis

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab

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p53 and its mutants in tumor cell migration and invasion

21 January 2018

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

21 January 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

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Phosphorylation of HDM2 by Akt.

21 January 2018

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Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.

21 January 2018

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Downregulation of wild-type p53 protein by HER-2/neu mediated PI3K pathway activation in human breast cancer cells: its effect on cell proliferation and implication for therapy.

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SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.

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Comprehensive field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma

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AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

21 January 2018

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Regulation of PTEN transcription by p53

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PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

21 January 2018

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p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment

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Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

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Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.

21 January 2018

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Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.

21 January 2018

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Molecular pathways: PI3K pathway targets in triple-negative breast cancers

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

21 January 2018

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PIK3CA mutation associates with improved outcome in breast cancer.

21 January 2018

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PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients

21 January 2018

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Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.

21 January 2018

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Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.

21 January 2018

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Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

21 January 2018

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PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma

21 January 2018

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Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway

21 January 2018

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

21 January 2018

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

21 January 2018

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Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report.

21 January 2018

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Development of PI3K inhibitors: lessons learned from early clinical trials

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Tumour biology: Policing of oncogene activity by p53

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BST20140070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25109960%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference