(Q38241234)

31 August 2017

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis (English)

1 reference

31 August 2017

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Jasper C A Broen

1

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31 August 2017

Timothy R D J Radstake

series ordinal

2

1 reference

31 August 2017

Marzia Rossato

series ordinal

3

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31 August 2017

language of work or name

English

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publication date

19 August 2014

1 reference

Nature Reviews Rheumatology

31 August 2017

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31 August 2017

10

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31 August 2017

11

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31 August 2017

671-681

1 reference

https://scigraph.springernature.com/pub.10.1038/nrrheum.2014.128

31 August 2017

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cites work

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Preliminary criteria for the classification of systemic sclerosis (scleroderma)

31 March 2020

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Autoantibodies in systemic sclerosis

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Deciphering the genetic background of systemic sclerosis

31 March 2020

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Association of the autoimmune disease scleroderma with an immunologic response to cancer

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Occupational silica exposure as a risk factor for scleroderma: a meta-analysis

31 March 2020

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Polyautoimmunity and familial autoimmunity in systemic sclerosis

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Familial risk estimation in systemic sclerosis

31 March 2020

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Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis

31 March 2020

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Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts

31 March 2020

1 reference

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Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Genetics of systemic sclerosis: an update

31 March 2020

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Association of STAT4 polymorphism with systemic sclerosis in a Japanese population

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

STAT4is a genetic risk factor for systemic sclerosis having additive effects withIRF5on disease susceptibility and related pulmonary fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

STAT4: genetics, mechanisms, and implications for autoimmunity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The role of OX40-mediated co-stimulation in T-cell activation and survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Association of the FAM167A-BLK region with systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Study of functional variants of theBANK1gene in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

BANK1is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects withIRF5andSTAT4

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

New insight on the Xq28 association with systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Independent replication establishes the CD247 gene as a genetic systemic sclerosis susceptibility factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The pathogenesis of systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Systemic sclerosis: environmental factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Epigenetic alterations in autoimmune rheumatic diseases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The epigenetics of autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

DNA demethylation of CD40l in CD4+ T cells from women with systemic sclerosis: a possible explanation for female susceptibility.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor ?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA array analysis of microRNAs related to systemic scleroderma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Role of MicroRNAs in Fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNAs and the regulation of fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA-29: a potential therapeutic target for systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Discoidin domain receptor 2-microRNA 196a-mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Detection of hair-microRNAs as the novel potent biomarker: evaluation of the usefulness for the diagnosis of scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor β.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Expression analysis of multiple microRNAs in each patient with scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Circulating miR-29a levels in patients with scleroderma spectrum disorder

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Circulating miR-142-3p levels in patients with systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

How birds of a feather flock together: genetics in autoimmune diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Linking disease associations with regulatory information in the human genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Systematic localization of common disease-associated variation in regulatory DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Variation in transcription factor binding among humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Human polymorphism at microRNAs and microRNA target sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

MicroRNA target site polymorphisms and human disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Cancer Systems Biology: a peek into the future of patient care?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2014.128

Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25136786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heritability of vasculopathy, autoimmune disease, and fibrosis in systemic sclerosis: a population-based study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25136786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2014.128

1 reference

Dimensions Publication ID

31 August 2017

0 references

1 reference