(Q38243667)

31 August 2017

The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway (English)

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31 August 2017

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Hong Yao

1

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31 August 2017

Xiangyang Han

series ordinal

2

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31 August 2017

Xiuzhen Han

series ordinal

3

1 reference

31 August 2017

1 December 2014

1 reference

American journal of cardiovascular drugs

31 August 2017

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31 August 2017

14

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31 August 2017

6

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31 August 2017

433-442

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https://scigraph.springernature.com/pub.10.1007/s40256-014-0089-9

31 August 2017

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cites work

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

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https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction

21 January 2018

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Cardioprotection: chances and challenges of its translation to the clinic

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardioprotective effects of insulin: how intensive insulin therapy may benefit cardiac surgery patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

21 January 2018

Insulin and the heart

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Oxidative stress and macrophage foam cell formation during diabetes mellitus-induced atherogenesis: role of insulin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin says NO to cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-bi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

PI3K/Akt signaling pathway involved in cardioprotection of preconditioning with high mobility group box 1 protein during myocardial ischemia and reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardiac regulation by phosphoinositide 3-kinases and PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Structure, regulation and function of PKB/AKT--a major therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Regulation of cell size and contractile function by AKT in cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Akt signalling in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Akt2 regulates cardiac metabolism and cardiomyocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Protein kinases and phosphatases in the control of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

The Impact of Overnutrition on Insulin Metabolic Signaling in the Heart and the Kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardiac mTOR protects the heart against ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Pretreatment with insulin before ischaemia reduces infarct size in Langendorff-perfused rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Polysaccharide from Fuzi likely protects against starvation-induced cytotoxicity in H9c2 cells by increasing autophagy through activation of the AMPK/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

MTOR overactivation and interrupted autophagy flux in obese hearts: a dicey assembly?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Regulation of cap-dependent translation by eIF4E inhibitory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Phosphoinositide 3-kinase γ inhibits cardiac GSK-3 independently of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Forkhead transcription factors and cardiovascular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Effect of persistent activation of phosphoinositide 3-kinase on heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

17beta-estradiol reduces cardiac hypertrophy mediated through the up-regulation of PI3K/Akt and the suppression of calcineurin/NF-AT3 signaling pathways in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Myocyte apoptosis in heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Neuronal nitric oxide synthase activation is involved in insulin-mediated cardiovascular effects in the nucleus tractus solitarii of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Different signaling pathways utilized by insulin to regulate the expression of ENT2, CNT1, CNT2 nucleoside transporters in rat cardiac fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

PI3K kinase and scaffold functions in heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin improves postischemic recovery of function through PI3K in isolated working rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin signaling: a possible pathogenesis of cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardiac insulin resistance and microRNA modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin signaling and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Autophagic predisposition in the insulin resistant diabetic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin resistance and heart failure: molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Insulin resistance: metabolic mechanisms and consequences in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40256-014-0089-9

10.1007/S40256-014-0089-9

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

31 August 2017

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1 reference