(Q38244951)

31 August 2017

title

Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo (English)

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31 August 2017

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7

Heiko van der Kuip

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Matthias Gutekunst

6

object named as

Matthias Gutekunst

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Catarina Brito

object named as

Catarina Brito

5

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author name string

John A Hickman

1

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31 August 2017

Ralph Graeser

2

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31 August 2017

Ronald de Hoogt

3

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31 August 2017

Suzana Vidic

4

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31 August 2017

Matthias Gutekunst

6

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31 August 2017

Heiko van der Kuip

7

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31 August 2017

IMI PREDECT Consortium

8

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31 August 2017

language of work or name

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1 September 2014

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31 August 2017

published in

Biotechnology Journal

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31 August 2017

volume

9

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31 August 2017

issue

9

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31 August 2017

page(s)

1115-1128

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

31 August 2017

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

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Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

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Spheroid-based drug screen: considerations and practical approach

21 January 2018

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A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro

21 January 2018

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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

21 January 2018

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Recent advances in three-dimensional multicellular spheroid culture for biomedical research

21 January 2018

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Dynamic analysis of hepatoma spheroid formation: roles of E-cadherin and beta1-integrin

21 January 2018

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Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor

21 January 2018

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Cell and environment interactions in tumor microregions: the multicell spheroid model

21 January 2018

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The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids

21 January 2018

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Acquired multicellular-mediated resistance to alkylating agents in cancer

21 January 2018

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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

Development of PI3K inhibitors: lessons learned from early clinical trials

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Brave little world: spheroids as an in vitro model to study tumor-immune-cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Development of an innovative 3D cell culture system to study tumour--stroma interactions in non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The tumor microenvironment is a dominant force in multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Matrix crosslinking forces tumor progression by enhancing integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Independent regulation of tumor cell migration by matrix stiffness and confinement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

A murine tumor producing a matrix of basement membrane

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

Matrigel: a complex protein mixture required for optimal growth of cell culture.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201300492

Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Janus-faced tumor microenvironment and redox

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Changing the energy habitat of the cancer cell in order to impact therapeutic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Process engineering of human pluripotent stem cells for clinical application

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Stem cell bioprocessing: fundamentals and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Microfabricated polymeric vessel mimetics for 3-D cancer cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Bioprocessing of human glioblastoma brain cancer tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Integrating human stem cell expansion and neuronal differentiation in bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Effects of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Semiautomatic growth analysis of multicellular tumor spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

3D cultures of human neural progenitor cells: dopaminergic differentiation and genetic modification. [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Three-dimensional HepaRG model as an attractive tool for toxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: morphologic and embryologic considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Using space-based investigations to inform cancer research on Earth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Microfluidics-assisted in vitro drug screening and carrier production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Physiologically relevant organs on chips

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Biomimetic tumor microenvironment on a microfluidic platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Miniaturized pre-clinical cancer models as research and diagnostic tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Patient-specific 3D microfluidic tissue model for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Influence of tumour micro-environment heterogeneity on therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Human cancer cell lines: fact and fantasy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The practicalities of using tissue slices as preclinical organotypic breast cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Human breast tumor slices: a model for identification of vitamin D regulated genes in the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Breast cancer tissue slices as a model for evaluation of response to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Preparation and culture of precision-cut organ slices from human and animal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Intratumor heterogeneity: evolution through space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Improved reproducibility in preparing precision-cut liver tissue slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

Integrin Signaling as a Cancer Drug Target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300492

21 January 2018

Identifiers

DOI

10.1002/BIOT.201300492

1 reference

31 August 2017

1 reference