(Q38260972)

1 September 2017

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title

Innate sensing of malaria parasites (English)

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1 September 2017

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Ricardo T Gazzinelli

1

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Douglas T Golenbock

series ordinal

4

object named as

Douglas T Golenbock

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1 September 2017

Parisa Kalantari

2

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PubMed ID

25324127

1 September 2017

Katherine A Fitzgerald

series ordinal

3

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1 September 2017

17 October 2014

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Nature Reviews Immunology

1 September 2017

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1 September 2017

14

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1 September 2017

11

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1 September 2017

744-757

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https://scigraph.springernature.com/pub.10.1038/nri3742

1 September 2017

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31 March 2020

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MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.

31 March 2020

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Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.

31 March 2020

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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

31 March 2020

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Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes

31 March 2020

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Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria

31 March 2020

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Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model

31 March 2020

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Immunological and inflammatory functions of the interleukin-1 family

31 March 2020

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Tumor necrosis factor: a pleiotropic cytokine and therapeutic target

31 March 2020

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The history of the malaria treatment of general paralysis.

31 March 2020

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Respiratory Manifestations of Malaria

31 March 2020

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Pathogenesis of malaria-associated acute respiratory distress syndrome.

31 March 2020

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Lethal malaria: Marchiafava and Bignami were right

31 March 2020

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Antigenic variation in Plasmodium falciparum

31 March 2020

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A family affair: var genes, PfEMP1 binding, and malaria disease

31 March 2020

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Cerebral malaria: we have come a long way

31 March 2020

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Pathogenesis, clinical features, and neurological outcome of cerebral malaria

31 March 2020

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Malaria in pregnancy: pathogenesis and immunity

31 March 2020

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Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria

31 March 2020

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Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes

31 March 2020

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Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

31 March 2020

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Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria

31 March 2020

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Approaching the asymptote? Evolution and revolution in immunology

31 March 2020

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Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity

31 March 2020

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Structure and dynamic behavior of Toll-like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols of Plasmodium falciparum

31 March 2020

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Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites

31 March 2020

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HDP-a novel heme detoxification protein from the malaria parasite

31 March 2020

1 reference

Intraleucocytic malaria pigment and prognosis in severe malaria

31 March 2020

1 reference

Synthetic Plasmodium-like hemozoin activates the immune response: a morphology - function study

31 March 2020

1 reference

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.

31 March 2020

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Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases

31 March 2020

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Malarial hemozoin is a Nalp3 inflammasome activating danger signal

31 March 2020

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Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

31 March 2020

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Involvement of inflammatory chemokines in survival of human monocytes fed with malarial pigment

31 March 2020

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Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes

31 March 2020

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Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action

31 March 2020

1 reference

Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria

31 March 2020

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Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

31 March 2020

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A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis

31 March 2020

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Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

31 March 2020

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The sterile inflammatory response

31 March 2020

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Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid

31 March 2020

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Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi

31 March 2020

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UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major

31 March 2020

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Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice

31 March 2020

1 reference

Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway

31 March 2020

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Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses

31 March 2020

1 reference

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

31 March 2020

1 reference

Plasmodium vivax: clinical spectrum, risk factors and pathogenesis

31 March 2020

1 reference

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

31 March 2020

1 reference

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

31 March 2020

1 reference

Toll-like receptor 7 mediates early innate immune responses to malaria

31 March 2020

1 reference

Interferon-mediated innate immune responses against malaria parasite liver stages

31 March 2020

1 reference

Tolerance, danger, and the extended family

31 March 2020

1 reference

The role of extracellular vesicles in Plasmodium and other protozoan parasites

31 March 2020

1 reference

A surprising role for uric acid: the inflammatory malaria response

31 March 2020

1 reference

Characterization of heme as activator of Toll-like receptor 4.

31 March 2020

1 reference

Overview of Circulating Nucleic Acids in Plasma/Serum

31 March 2020

1 reference

Development of TLR inhibitors for the treatment of autoimmune diseases

31 March 2020

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Plasma circulating nucleic acids levels increase according to the morbidity of Plasmodium vivax malaria

31 March 2020

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Plasmodium-induced inflammation by uric acid

31 March 2020

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Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria

31 March 2020

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Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation

31 March 2020

1 reference

Augmented plasma microparticles during acute Plasmodium vivax infection

31 March 2020

1 reference

Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum

31 March 2020

1 reference

Different faces of the heme-heme oxygenase system in inflammation

31 March 2020

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Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

31 March 2020

1 reference

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

31 March 2020

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Increased carboxyhemoglobin in adult falciparum malaria is associated with disease severity and mortality

31 March 2020

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Metabolic adaptation to tissue iron overload confers tolerance to malaria.

31 March 2020

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Immune mechanisms in malaria: new insights in vaccine development

31 March 2020

1 reference

Innate immunity to malaria

31 March 2020

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Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria.

31 March 2020

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Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.

31 March 2020

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Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice.

31 March 2020

1 reference

Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes

31 March 2020

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Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes

31 March 2020

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Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria.

31 March 2020

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Interleukin 12 induction of interferon gamma-dependent protection against malaria

31 March 2020

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IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice.

31 March 2020

1 reference

What really happens to dendritic cells during malaria?

31 March 2020

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Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation

31 March 2020

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Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression

31 March 2020

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TLR9 and MyD88 are crucial for the development of protective immunity to malaria

31 March 2020

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Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host.

31 March 2020

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Plasmodium strain determines dendritic cell function essential for survival from malaria

31 March 2020

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IFN-γ-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria

31 March 2020

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MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection

31 March 2020

1 reference

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

31 March 2020

1 reference

Type I interferons suppress CD4⁺ T-cell-dependent parasite control during blood-stage Plasmodium infection.

31 March 2020

1 reference

Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity

31 March 2020

1 reference

Cutting edge: the acquisition of TLR tolerance during malaria infection impacts T cell activation.

31 March 2020

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Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells.

31 March 2020

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Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria

31 March 2020

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Protection against a malaria challenge by sporozoite inoculation

31 March 2020

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Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine

31 March 2020

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First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

31 March 2020

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Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

31 March 2020

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Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria.

31 March 2020

1 reference

A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea.

31 March 2020

1 reference

A field trial to assess a blood-stage malaria vaccine

31 March 2020

1 reference

Naturally acquired Duffy-binding protein-specific binding inhibitory antibodies confer protection from blood-stage Plasmodium vivax infection

31 March 2020

1 reference

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

31 March 2020

1 reference

Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets

31 March 2020

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Plasmodium falciparum infection causes proinflammatory priming of human TLR responses

31 March 2020

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Enhanced toll-like receptor responsiveness associated with mitogen-activated protein kinase activation in Plasmodium falciparum-infected children

31 March 2020

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Neutrophil paralysis in Plasmodium vivax malaria.

31 March 2020

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Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

31 March 2020

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Plasmodium falciparum malaria and Salmonella infections in Gambian children

31 March 2020

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Bacteraemia complicating severe malaria in children.

31 March 2020

1 reference

Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome.

31 March 2020

1 reference

Bacteremia in Kenyan children presenting with malaria

31 March 2020

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Invasive non-Typhi Salmonella disease in Africa

31 March 2020

1 reference

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

31 March 2020

1 reference

Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization

31 March 2020

1 reference

Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function

31 March 2020

1 reference

Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction

31 March 2020

1 reference

Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.

31 March 2020

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MyD88 signaling is directly involved in the development of murine placental malaria

31 March 2020

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Pathological role of Toll-like receptor signaling in cerebral malaria.

31 March 2020

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Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria

31 March 2020

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Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor

31 March 2020

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Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria

31 March 2020

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Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

31 March 2020

1 reference

Pentoxifylline as an ancillary treatment for severe falciparum malaria in Thailand.

31 March 2020

1 reference

IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice

31 March 2020

1 reference

Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA.

31 March 2020

1 reference

Recombinant human IFN-alpha inhibits cerebral malaria and reduces parasite burden in mice

31 March 2020

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Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

31 March 2020

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Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia

31 March 2020

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Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

31 March 2020

1 reference

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria

31 March 2020

1 reference

Evidence that interferon-gamma plays a protective role during cerebral malaria

31 March 2020

1 reference

IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil

31 March 2020

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CD40L association with protection from severe malaria

31 March 2020

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Inducible nitric oxide synthase polymorphism and fatal cerebral malaria.

31 March 2020

1 reference

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria

31 March 2020

1 reference

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy

31 March 2020

1 reference

TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria

31 March 2020

1 reference

Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria.

31 March 2020

1 reference

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

31 March 2020

1 reference

The activation of vivax malaria hypnozoites by infectious diseases

31 March 2020

1 reference

Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential

31 March 2020

1 reference

Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system.

31 March 2020

1 reference

The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria

31 March 2020

1 reference

Biochemical characterization of Plasmodium falciparum hemozoin.

31 March 2020

1 reference

12 December 2020

Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma

1 reference

12 December 2020

IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism.

1 reference

12 December 2020

Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway.

1 reference

12 December 2020

Phagocytosis of the malarial pigment, hemozoin, impairs expression of major histocompatibility complex class II antigen, CD54, and CD11c in human monocytes

1 reference

12 December 2020

Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosi

1 reference

12 December 2020

Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses.

1 reference

12 December 2020

Anti-TNF therapy inhibits fever in cerebral malaria.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3742

1 reference

PubMed ID

25324127

Dimensions Publication ID

1 September 2017

0 references

1 reference

PubMed ID

25324127