(Q38261749)

1 September 2017

1 reference

title

AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity (English)

1 reference

1 September 2017

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Svend K Petersen-Mahrt

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

1 January 2014

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1 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

427-443

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

Instability and decay of the primary structure of DNA

6 June 2020

cites work

1 reference

Immunity through DNA deamination

21 January 2018

1 reference

DNA deamination in immunity

21 January 2018

1 reference

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

21 January 2018

1 reference

Molecular cloning of an apolipoprotein B messenger RNA editing protein

21 January 2018

1 reference

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

21 January 2018

1 reference

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

5-Methylcytosine DNA demethylation: more than losing a methyl group

21 January 2018

1 reference

Innate immune recognition

21 January 2018

1 reference

Molecular mechanisms of antibody somatic hypermutation.

21 January 2018

1 reference

Mechanisms of programmed DNA lesions and genomic instability in the immune system.

21 January 2018

1 reference

The biochemistry of somatic hypermutation

21 January 2018

1 reference

Mechanism and regulation of class switch recombination

21 January 2018

1 reference

The AID-induced DNA damage response in chromatin

21 January 2018

1 reference

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

1 reference

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

1 reference

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

1 reference

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

1 reference

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

21 January 2018

1 reference

Somatic hypermutation of the AID transgene in B and non-B cells

21 January 2018

1 reference

Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes

21 January 2018

1 reference

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

1 reference

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

21 January 2018

1 reference

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

21 January 2018

1 reference

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

1 reference

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

1 reference

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

21 January 2018

1 reference

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

1 reference

Mismatch repair co-opted by hypermutation.

21 January 2018

1 reference

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

21 January 2018

1 reference

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

21 January 2018

1 reference

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

21 January 2018

1 reference

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

1 reference

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

21 January 2018

1 reference

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

21 January 2018

1 reference

Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice

21 January 2018

1 reference

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

21 January 2018

1 reference

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination

21 January 2018

1 reference

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

21 January 2018

1 reference

Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination

21 January 2018

1 reference

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

21 January 2018

1 reference

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

21 January 2018

1 reference

Regulating post-translational modifications of the eukaryotic replication clamp PCNA.

21 January 2018

1 reference

A role for PCNA ubiquitination in immunoglobulin hypermutation

21 January 2018

1 reference

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

21 January 2018

1 reference

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

21 January 2018

1 reference

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

21 January 2018

1 reference

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

21 January 2018

1 reference

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

21 January 2018

1 reference

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

21 January 2018

1 reference

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

1 reference

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

21 January 2018

1 reference

AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

21 January 2018

1 reference

A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

21 January 2018

1 reference

An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability

21 January 2018

1 reference

Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression

21 January 2018

1 reference

Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility

21 January 2018

1 reference

In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

21 January 2018

1 reference

APOBEC-mediated editing of viral RNA.

21 January 2018

1 reference

The antiretroviral potency of APOBEC1 deaminase from small animal species

21 January 2018

1 reference

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

21 January 2018

1 reference

APOBEC1-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis

21 January 2018

1 reference

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

21 January 2018

1 reference

Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation

21 January 2018

1 reference

Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes

21 January 2018

1 reference

Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor

21 January 2018

1 reference

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

21 January 2018

1 reference

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

21 January 2018

1 reference

DNA deamination mediates innate immunity to retroviral infection

21 January 2018

1 reference

Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

21 January 2018

1 reference

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

21 January 2018

1 reference

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

21 January 2018

1 reference

Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration

21 January 2018

1 reference

The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

21 January 2018

1 reference

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

21 January 2018

1 reference

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway

21 January 2018

1 reference

The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

21 January 2018

1 reference

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular Stability

21 January 2018

1 reference

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

21 January 2018

1 reference

Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family

21 January 2018

1 reference

Restriction of foamy viruses by APOBEC cytidine deaminases

21 January 2018

1 reference

Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases

21 January 2018

1 reference

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

21 January 2018

1 reference

Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H

21 January 2018

1 reference

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution

21 January 2018

1 reference

Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1

21 January 2018

1 reference

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

21 January 2018

1 reference

Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets

21 January 2018

1 reference

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

21 January 2018

1 reference

Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection

21 January 2018

1 reference

Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification

21 January 2018

1 reference

Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C.

21 January 2018

1 reference

Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication

21 January 2018

1 reference

Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G-->A hypermutation

21 January 2018

1 reference

Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.

21 January 2018

1 reference

Dual effect of APOBEC3G on Hepatitis B virus

21 January 2018

1 reference

G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection

21 January 2018

1 reference

G to A hypermutation of hepatitis B virus.

21 January 2018

1 reference

Comment on "Inhibition of hepatitis B virus replication by APOBEC3G".

21 January 2018

1 reference

Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo

21 January 2018

1 reference

Inhibition of hepatitis B virus replication by APOBEC3G.

21 January 2018

1 reference

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

21 January 2018

1 reference

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

21 January 2018

1 reference

Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase

21 January 2018

1 reference

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

21 January 2018

1 reference

APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.

21 January 2018

1 reference

G to A hypermutation of TT virus.

21 January 2018

1 reference

Active transposition in genomes

21 January 2018

1 reference

APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.

21 January 2018

1 reference

Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses

21 January 2018

1 reference

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast

21 January 2018

1 reference

APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells

21 January 2018

1 reference

Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.

21 January 2018

1 reference

Selective inhibition of Alu retrotransposition by APOBEC3G.

21 January 2018

1 reference

APOBEC3 proteins inhibit human LINE-1 retrotransposition

21 January 2018

1 reference

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism

21 January 2018

1 reference

High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

21 January 2018

1 reference

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

1 reference

AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity

21 January 2018

1 reference

LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase

21 January 2018

1 reference

DNA methylation patterns and epigenetic memory

21 January 2018

1 reference

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

21 January 2018

1 reference

Active demethylation of the paternal genome in the mouse zygote

21 January 2018

1 reference

Dynamic reprogramming of DNA methylation in the early mouse embryo.

21 January 2018

1 reference

Active DNA demethylation: many roads lead to Rome.

21 January 2018

1 reference

Estrogen directly activates AID transcription and function

21 January 2018

1 reference

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

1 reference

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

21 January 2018

1 reference

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

21 January 2018

1 reference

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation

21 January 2018

1 reference

APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family

21 January 2018

1 reference

Mice deficient in APOBEC2 and APOBEC3.

21 January 2018

1 reference

Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy

21 January 2018

1 reference

Zebrafish AID is capable of deaminating methylated deoxycytidines

21 January 2018

1 reference

Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b

21 January 2018

1 reference

APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis.

21 January 2018

1 reference

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

21 January 2018

1 reference

A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells

21 January 2018

1 reference

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.

21 January 2018

1 reference

DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

21 January 2018

1 reference

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

21 January 2018

1 reference

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

21 January 2018

1 reference

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

21 January 2018

1 reference

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.

21 January 2018

1 reference

Differential L1 regulation in pluripotent stem cells of humans and apes.

21 January 2018

1 reference

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

1 reference

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

21 January 2018

1 reference

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

21 January 2018

1 reference

AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud

21 January 2018

1 reference

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

21 January 2018

1 reference

Epigenetic reprogramming during early development in mammals.

21 January 2018

1 reference

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

21 January 2018

1 reference

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

21 January 2018

1 reference

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

21 January 2018

1 reference

Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

21 January 2018

1 reference

Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.

21 January 2018

1 reference

Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development

21 January 2018

1 reference

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway

21 January 2018

1 reference

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

21 January 2018

1 reference

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

1 reference

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

21 January 2018

1 reference

Mammalian mismatch repair: error-free or error-prone?

21 January 2018

1 reference

Expression profiling of DNA repair genes in human oocytes and blastocysts using microarrays.

21 January 2018

1 reference

Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays

21 January 2018

1 reference

Two levels of protection for the B cell genome during somatic hypermutation.

21 January 2018

1 reference

The AID dilemma: infection, or cancer?

21 January 2018

1 reference

Hormones and AID: balancing immunity and autoimmunity

21 January 2018

1 reference

Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo

21 January 2018

1 reference

Epigenetic reprogramming in mouse primordial germ cells

21 January 2018

1 reference

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

1 reference

Demethylation of the zygotic paternal genome

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.14.35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25333851%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference