(Q38284376)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

review article

1 reference

title

The role of protein clearance mechanisms in organismal ageing and age-related diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Isabel Saez

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Andrew Dillin

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

language of work or name

English

0 references

publication date

8 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

1

1 reference

28 June 2019

page(s)

5659

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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21 January 2018

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21 January 2018

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alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

21 January 2018

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Autophagy mediates the mitotic senescence transition

21 January 2018

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Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.

21 January 2018

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Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)

21 January 2018

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Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome?

21 January 2018

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Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function

21 January 2018

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Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae

21 January 2018

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Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Proteasome activation as a novel antiaging strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

21 January 2018

The genetics of ageing

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

TFEB links autophagy to lysosomal biogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Proteasome activator enhances survival of Huntington's disease neuronal model cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6659

Association of FOXO3A variation with human longevity confirmed in German centenarians

21 January 2018

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

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Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.

21 January 2018

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Autophagy genes are essential for dauer development and life-span extension in C. elegans

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

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The insulin paradox: aging, proteotoxicity and neurodegeneration

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21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Opposing activities protect against age-onset proteotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Growth hormone, insulin and aging: the benefits of endocrine defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Two neurons mediate diet-restriction-induced longevity in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

Autophagy is required for dietary restriction-mediated life span extension in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

https://api.crossref.org/works/10.1038%2FNCOMMS6659

1 reference

7 January 2021

Altered proteasome structure, function, and oxidation in aged muscle

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Chaperone function and chaperone overload in the aged. A preliminary analysis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Regulation of amyloid precursor protein processing by the Beclin 1 complex

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Fibroblast cultures from healthy centenarians have an active proteasome

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Overexpression of Atg5 in mice activates autophagy and extends lifespan

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Autophagy - An Emerging Anti-Aging Mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

A conserved ubiquitination pathway determines longevity in response to diet restriction

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6659

7 January 2021

Identifiers

DOI

10.1038/NCOMMS6659

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482515%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 February 2020

ADS bibcode

2014NatCo...5.5659V

0 references

1020334275

0 references

1 reference