(Q38293233)

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6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

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1 September 2017

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. (English)

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1 September 2017

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Peter Nürnberg

13

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Peter Nürnberg

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1 September 2017

Ulrich M. Zanger

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Ulrich M Zanger

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1 September 2017

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Daniel Janke

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Sherif Mehralivand

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Dennis Strand

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Ute Gödtel-Armbrust

4

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Alice Habermeier

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Ulrike Gradhand

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Christine Fischer

7

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Mohammad R Toliat

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Peter Fritz

9

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Matthias Schwab

11

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Martin F Fromm

12

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Leszek Wojnowski

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Ellen I Closs

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Thomas Lang

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1 May 2008

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29

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5

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659-669

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1 September 2017

Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing

1 reference

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Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage

1 reference

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Multidrug resistance-associated proteins 3, 4, and 5.

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Functional expression of murine multidrug resistance in Xenopus laevis oocytes

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Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

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Insight in eukaryotic ABC transporter function by mutation analysis

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Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

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Amino acid difference formula to help explain protein evolution

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The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation

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6-thioguanine--efficacy and safety in chronic active Crohn's disease

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Influence of omeprazole on multidrug resistance protein 3 expression in human liver

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N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter.

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The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

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Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis

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Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

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Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

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Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

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Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein

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Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

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Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis

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6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease

1 reference

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SIFT: Predicting amino acid changes that affect protein function

1 reference

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21 January 2018

Human non-synonymous SNPs: server and survey

1 reference

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The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

1 reference

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Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

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Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

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Role of MRP4 and MRP5 in biology and chemotherapy

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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

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Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

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21 January 2018

Human multidrug resistance associated protein 4 confers resistance to camptothecins.

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21 January 2018

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

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The use of Xenopus laevis oocytes for the functional characterization of heterologously expressed membrane proteins

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Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

1 reference

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Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

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Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

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7 January 2021

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Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

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Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

1 reference

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Identifiers

10.1002/HUMU.20694

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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