(Q38298765)

1 September 2017

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance (English)

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1 September 2017

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14

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1 September 2017

16

Eystein S Husebye

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1 September 2017

17

Jakub Abramson

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1 September 2017

Anna Chuprin

1

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1 September 2017

Ayelet Avin

2

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1 September 2017

Yael Goldfarb

3

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1 September 2017

Yonatan Herzig

4

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1 September 2017

Ben Levi

5

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1 September 2017

Adi Jacob

6

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1 September 2017

Asaf Sela

7

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1 September 2017

Shir Katz

8

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1 September 2017

Moran Grossman

9

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1 September 2017

Clotilde Guyon

10

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1 September 2017

Moran Rathaus

11

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1 September 2017

Haim Y Cohen

12

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1 September 2017

Irit Sagi

13

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1 September 2017

Michael W McBurney

15

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1 September 2017

language of work or name

English

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publication date

25 May 2015

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1 September 2017

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1 September 2017

16

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1 September 2017

7

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1 September 2017

737-745

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1 September 2017

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Thymic epithelial cells: working class heroes for T cell development and repertoire selection

21 January 2018

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

21 January 2018

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The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development

21 January 2018

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Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

21 January 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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21 January 2018

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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

21 January 2018

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The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

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Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

21 January 2018

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AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

21 January 2018

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Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

21 January 2018

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AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

21 January 2018

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Aire's partners in the molecular control of immunological tolerance

21 January 2018

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DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

21 January 2018

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Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

21 January 2018

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The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

21 January 2018

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SIRT1: recent lessons from mouse models.

21 January 2018

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Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

21 January 2018

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Deletional tolerance mediated by extrathymic Aire-expressing cells

21 January 2018

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SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.

21 January 2018

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Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus

21 January 2018

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Transcriptional targets of sirtuins in the coordination of mammalian physiology

21 January 2018

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SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions

21 January 2018

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

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SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice.

21 January 2018

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Autoimmune regulator is acetylated by transcription coactivator CBP/p300.

21 January 2018

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Modifier loci condition autoimmunity provoked by Aire deficiency

21 January 2018

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Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

21 January 2018

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The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

21 January 2018

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Sirtuin 1 in immune regulation and autoimmunity

21 January 2018

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Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

21 January 2018

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Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

21 January 2018

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Identification of a SIRT1 mutation in a family with type 1 diabetes

21 January 2018

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Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis

21 January 2018

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Proteome-wide prediction of acetylation substrates

21 January 2018

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sirt1-null mice develop an autoimmune-like condition

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26006015

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26006015

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26006015

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3194

1 reference

1 September 2017

1 reference