(Q38300447)

1 September 2017

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title

The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome (English)

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1 September 2017

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Zhiguo Zhang

1

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1 September 2017

Shanshan Zhou

2

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1 September 2017

Xin Jiang

3

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1 September 2017

Yue-Hui Wang

4

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1 September 2017

Fengsheng Li

5

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1 September 2017

Yong-Gang Wang

6

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1 September 2017

Yang Zheng

7

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1 September 2017

Lu Cai

8

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1 September 2017

language of work or name

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1 March 2015

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Reviews in Endocrine and Metabolic Disorders

1 September 2017

published in

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1 September 2017

volume

16

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1 September 2017

issue

1

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1 September 2017

page(s)

35-45

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https://scigraph.springernature.com/pub.10.1007/s11154-014-9305-9

1 September 2017

exact match

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Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

21 January 2018

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Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

21 January 2018

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

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21 January 2018

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21 January 2018

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The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

21 January 2018

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Antioxidants prevent health-promoting effects of physical exercise in humans

21 January 2018

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Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.

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An integrated medical treatment for type-2 diabetes.

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Type 2 diabetes as a redox disease

21 January 2018

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Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity.

21 January 2018

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21 January 2018

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21 January 2018

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Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice

21 January 2018

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Fibroblast growth factor 21: from pharmacology to physiology

21 January 2018

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Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

21 January 2018

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Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity

21 January 2018

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Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury

21 January 2018

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Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

21 January 2018

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Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome

21 January 2018

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Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

21 January 2018

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Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

21 January 2018

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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

21 January 2018

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Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion

21 January 2018

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Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications

21 January 2018

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Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

21 January 2018

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Insulin resistance is a cellular antioxidant defense mechanism

21 January 2018

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21 January 2018

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21 January 2018

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ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

21 January 2018

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Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Foxo1 integrates insulin signaling with mitochondrial function in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Beneficial role of Nrf2 in regulating NADPH generation and consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Adipose development: from stem cell to adipocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

The transcriptional basis of adipocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Emerging role of Nrf2 in adipocytes and adipose biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

The Keap1-Nrf2 system prevents onset of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Does increased oxidative stress cause hypertension?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Oxidative stress in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-014-9305-9

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, i

21 January 2018

1 reference

12 December 2020

Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy

1 reference

12 December 2020

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

1 reference

12 December 2020

Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

1 reference

12 December 2020

Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo

1 reference

12 December 2020

Curcumin decreases oleic acid-induced lipid accumulation via AMPK phosphorylation in hepatocarcinoma cells

1 reference

12 December 2020

Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

1 reference

12 December 2020

10.1007/S11154-014-9305-9

Identifiers

DOI

1 reference

Dimensions Publication ID

1 September 2017

1000857641

0 references

1 reference