(Q38311394)

2 September 2017

The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis (English)

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2 September 2017

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Zhu H

1

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2 September 2017

Fu W

series ordinal

2

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2 September 2017

Mattson MP

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

1 July 2000

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Journal of Neurochemistry

2 September 2017

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2 September 2017

75

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2 September 2017

117-124

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2 September 2017

1

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DNA strand breaks in Alzheimer's disease.

2 September 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

DNA damage, mutation and fine structure DNA repair in aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Bcl-2 facilitates recovery from DNA damage after oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

The RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Telomerase activity, cell proliferation, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Telomere loss: mitotic clock or genetic time bomb?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Human telomerase contains evolutionarily conserved catalytic and structural subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Reverse transcriptase motifs in the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Telomeres, telomerase, and immortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Differentiation of immortal cells inhibits telomerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Evidence for apoptotic cell death in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Bcl-2 and Bax protein expression in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Control of telomere length by the human telomeric protein TRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2000.0750117.X

10.1046/J.1471-4159.2000.0750117.X

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference