(Q38316915)

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Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice (English)

1 reference

Europe PubMed Central

2 September 2017

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4

1 reference

Europe PubMed Central

2 September 2017

5

object named as

Paul Jolicoeur

1 reference

Europe PubMed Central

2 September 2017

author name string

Patrick Vincent

1

1 reference

Europe PubMed Central

2 September 2017

Elena Priceputu

2

1 reference

Europe PubMed Central

2 September 2017

Denis Kay

3

1 reference

Europe PubMed Central

2 September 2017

Zaher Hanna

6

1 reference

Europe PubMed Central

2 September 2017

language of work or name

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publication date

28 December 2005

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Europe PubMed Central

2 September 2017

number of pages

15

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

2 September 2017

281

1 reference

Europe PubMed Central

2 September 2017

11

1 reference

Europe PubMed Central

2 September 2017

6940-6954

1 reference

Europe PubMed Central

2 September 2017

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV accessory proteins: leading roles for the supporting cast.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV-1: is Nef a PAK animal?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The numerous effector functions of Nef.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV and SIV Nef modulate signal transduction and protein sorting in T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The positive influence of Nef on viral infectivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV: a new role for Nef in the spread of HIV.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Analysis of Nef-induced MHC-I endocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Mechanism for down-regulation of CD28 by Nef.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Nef and the Nef-associated kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Identification of the Nef-associated kinase as p21-activated kinase 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Lentivirus Nef specifically activates Pak2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated Nef

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleuk

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Negative control of the Myc protein by the stress-responsive kinase Pak2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512710200

21 January 2018

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10.1074/JBC.M512710200

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Europe PubMed Central

2 September 2017

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https://api.fatcat.wiki/v0/release/vhrvjnsq4renfpgqdk3fkf3noy

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Europe PubMed Central

2 September 2017

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