(Q45046886)

English

In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice

scientific article published in October 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 December 2017

In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice (English)

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Europe PubMed Central

PubMed publication ID

8 December 2017

mutational analysis

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inferred from title

6

object named as

Paul Jolicoeur

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Europe PubMed Central

PubMed publication ID

8 December 2017

Johanne Poudrier

4

object named as

Johanne Poudrier

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

Elena Priceputu

2

object named as

Elena Priceputu

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

author name string

Zaher Hanna

1

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Europe PubMed Central

PubMed publication ID

8 December 2017

Denis G Kay

3

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Europe PubMed Central

PubMed publication ID

8 December 2017

Pavel Chrobak

5

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Europe PubMed Central

PubMed publication ID

8 December 2017

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publication date

1 October 2004

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Europe PubMed Central

PubMed publication ID

8 December 2017

number of pages

14

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Europe PubMed Central

PubMed publication ID

8 December 2017

327

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Europe PubMed Central

PubMed publication ID

8 December 2017

2

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Europe PubMed Central

PubMed publication ID

8 December 2017

273-286

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Europe PubMed Central

PubMed publication ID

8 December 2017

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

A proposed mechanism for the induction of activator protein 1 (AP-1) binding by HIV-1 negative factor(Nef) in the macrophage cell line RAW267.4 cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Live and let die: Nef functions beyond HIV replication

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Structure--function relationships in HIV-1 Nef.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV: a new role for Nef in the spread of HIV.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Analysis of Nef-induced MHC-I endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Determination of lymphocyte division by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-gamma and IL-6

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Mechanism for down-regulation of CD28 by Nef.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV accessory proteins: leading roles for the supporting cast.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

based on heuristic

inferred from DOI database lookup

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

based on heuristic

inferred from DOI database lookup

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

based on heuristic

inferred from DOI database lookup

Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.06.028

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/J.VIROL.2004.06.028

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

ResearchGate publication ID

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