(Q38323233)

2 September 2017

title

Inhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways (English)

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2 September 2017

Gaurav Pathria

1

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2 September 2017

Christine Wagner

series ordinal

2

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2 September 2017

Stephan N Wagner

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

26 July 2012

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Journal of Investigative Dermatology

2 September 2017

published in

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2 September 2017

volume

132

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2 September 2017

issue

12

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2 September 2017

page(s)

2780-2790

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https://scigraph.springernature.com/pub.10.1038/jid.2012.233

2 September 2017

exact match

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cites work

Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.

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PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Fisetin: a natural fist against melanoma?

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7 January 2021

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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7 January 2021

ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence

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7 January 2021

Survivin withdrawal by nuclear export failure as a physiological switch to commit cells to apoptosis.

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7 January 2021

Genomic analysis of metastasis reveals an essential role for RhoC

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7 January 2021

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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7 January 2021

Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma

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7 January 2021

RSK and MSK in MAP kinase signalling

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7 January 2021

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

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7 January 2021

Anticancer therapy: boosting the bang of Bim.

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Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.

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7 January 2021

Polo-like kinase 1 is a potential therapeutic target in human melanoma

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7 January 2021

Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation

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7 January 2021

Nuclear transport and cancer: from mechanism to intervention

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7 January 2021

Nuclear export is essential for the tumor-promoting activity of survivin.

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7 January 2021

Nucleocytoplasmic transport: Ran, beta and beyond

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NESbase version 1.0: a database of nuclear export signals

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Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line

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Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

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hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways.

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7 January 2021

Rewired ERK-JNK signaling pathways in melanoma

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7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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7 January 2021

Mdm2-mediated ubiquitylation: p53 and beyond.

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7 January 2021

Identification of nuclear export inhibitors with potent anticancer activity in vivo

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7 January 2021

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

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7 January 2021

CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin

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7 January 2021

Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes.

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7 January 2021

CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

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7 January 2021

Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.

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7 January 2021

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

The mammalian Mog1 protein is a guanine nucleotide release factor for Ran

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Sef is a spatial regulator for Ras/MAP kinase signaling

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

CRM1-mediated nuclear export of proteins and drug resistance in cancer

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Identification of a signal for rapid export of proteins from the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Recurrent patterns of dual RB and p53 pathway inactivation in melanoma

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https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

1 reference

https://api.crossref.org/works/10.1038%2FJID.2012.233

7 January 2021

Identifiers

DOI

10.1038/JID.2012.233

1 reference

Dimensions Publication ID

2 September 2017

1042858379

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1 reference