Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q37508606)
Watch
English
Mdm2-mediated ubiquitylation: p53 and beyond.
scientific article published on January 2010
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
Mdm2-mediated ubiquitylation: p53 and beyond
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
main subject
ubiquitination
1 reference
based on heuristic
inferred from title
author
Jean-Christophe Marine
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
author name string
G Lozano
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
publication date
1 January 2010
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
published in
Cell Death & Differentiation
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
volume
17
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
page(s)
93-102
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/cdd.2009.68
0 references
cites work
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functions of the MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-Mdm2 module and the ubiquitin system.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 in growth signaling and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm2 expression is induced by wild type p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamics of the p53-Mdm2 feedback loop in individual cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oscillations and variability in the p53 system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oscillations by the p53-Mdm2 feedback loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of p53-mediated transcription by MDM2: a dual mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acetylation is indispensable for p53 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles of Mdm2 and Mdm4 in red cell production.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 ubiquitination: Mdm2 and beyond
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression and normal aging in mice with constitutively high p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 polymorphisms: cancer implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-terminal ubiquitination of p53 contributes to nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Fos Proto-Oncoprotein Is Degraded by the Proteasome Independently of Its Own Ubiquitinylation In Vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical contribution of the MDM2 acidic domain to p53 ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Mdm2-directed degradation by the C terminus of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of the polyubiquitin proteolytic signal
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Divorcing ARF and p53: an unsettled case
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDMX: from bench to bedside
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asymmetric cell division.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NUMB controls p53 tumour suppressor activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Yin Yang 1 is a negative regulator of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RYBP stabilizes p53 by modulating MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unlocking the Mdm2-p53 loop: ubiquitin is the key.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleolar Arf sequesters Mdm2 and activates p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical and functional interactions between PML and MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdmx as an essential regulator of p53 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel cofactor for p300 that regulates the p53 response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 targets the p53 transcription cofactor JMY for degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 regulates dihydrofolate reductase activity through monoubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The genetics of the p53 pathway, apoptosis and cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes genetic instability and transformation independent of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modeling the therapeutic efficacy of p53 restoration in tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of p53 function leads to tumour regression in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCDD.2009.68
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/CDD.2009.68
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
PubMed ID
19498444
1 reference
stated in
Europe PubMed Central
PubMed ID
19498444
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19498444%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
ResearchGate publication ID
26268641
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
