(Q39983426)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

0 references

1

1 reference

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7 January 2020

Alexander Loewer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Caroline S Mock

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Irun Bhan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Galit Lahav

5

1 reference

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7 January 2020

publication date

1 May 2008

1 reference

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7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

277-289

1 reference

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7 January 2020

issue

3

1 reference

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describes a project that uses

7 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2579769/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

1 reference

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

22 September 2017

1 reference

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A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Oscillations and variability in the p53 system

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

An excitable gene regulatory circuit induces transient cellular differentiation

22 September 2017

1 reference

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

22 September 2017

1 reference

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

22 September 2017

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

22 September 2017

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

22 September 2017

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A plausible model for the digital response of p53 to DNA damage.

22 September 2017

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

22 September 2017

1 reference

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The p53 pathway: positive and negative feedback loops

22 September 2017

1 reference

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Steady states and oscillations in the p53/Mdm2 network.

22 September 2017

1 reference

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The strength of indecisiveness: oscillatory behavior for better cell fate determination

22 September 2017

1 reference

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

22 September 2017

1 reference

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Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

22 September 2017

1 reference

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The negative role of cyclin G in ATM-dependent p53 activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics.

22 September 2017

1 reference

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Dynamics of the p53-Mdm2 feedback loop in individual cells

22 September 2017

1 reference

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A quantitative description of membrane current and its application to conduction and excitation in nerve

22 September 2017

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Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

22 September 2017

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

22 September 2017

1 reference

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

22 September 2017

1 reference

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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

22 September 2017

1 reference

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

22 September 2017

1 reference

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

22 September 2017

1 reference

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Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.

22 September 2017

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Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

22 September 2017

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

22 September 2017

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

22 September 2017

1 reference

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

22 September 2017

1 reference

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Regulation of p53 stability by Mdm2

22 September 2017

1 reference

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Mdm2 promotes the rapid degradation of p53

22 September 2017

1 reference

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p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

mdm2 expression is induced by wild type p53 activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

The p53-mdm-2 autoregulatory feedback loop

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Modeling the cell division cycle: cdc2 and cyclin interactions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Oscillatory behavior in enzymatic control processes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579769

Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging

1 October 2018

1 reference

12 December 2020

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

1 reference

12 December 2020

The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

1 reference

12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

10.1016/J.MOLCEL.2008.03.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18471974%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference