(Q38331952)

2 September 2017

title

Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator (English)

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2 September 2017

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3

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2 September 2017

Cameron P Bracken

1

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2 September 2017

Murray L Whitelaw

series ordinal

2

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2 September 2017

language of work or name

English

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publication date

13 January 2005

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

280

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2 September 2017

issue

14

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2 September 2017

page(s)

14240-14251

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

2 September 2017

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

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The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

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Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

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Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia

21 January 2018

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

21 January 2018

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Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor

21 January 2018

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Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins

21 January 2018

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Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor

21 January 2018

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Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

21 January 2018

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

21 January 2018

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Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

21 January 2018

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Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex

21 January 2018

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Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

21 January 2018

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Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains

21 January 2018

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Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway

21 January 2018

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

21 January 2018

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

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Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression

21 January 2018

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An essential role for p300/CBP in the cellular response to hypoxia

21 January 2018

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Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

21 January 2018

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Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

21 January 2018

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

21 January 2018

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Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

21 January 2018

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Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

21 January 2018

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Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

21 January 2018

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HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

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HIF activation by pH-dependent nucleolar sequestration of VHL.

21 January 2018

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The subtle side to hypoxia inducible factor (HIFalpha) regulation

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance

21 January 2018

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Subcellular localization and regulation of hypoxia-inducible factor-2alpha in vascular endothelial cells

21 January 2018

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Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy

21 January 2018

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Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia

21 January 2018

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

21 January 2018

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Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

21 January 2018

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Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium

21 January 2018

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M409987200

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

KSHV vFLIP binds to IKK-gamma to activate IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-kappa B) pathway activation: IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stim

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409987200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409987200

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2 September 2017

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