(Q38335343)

English

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species (English)

1 reference

Europe PubMed Central

2 September 2017

phosphorylation

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reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Ebba U Kurz

1

1 reference

Europe PubMed Central

2 September 2017

Pauline Douglas

2

1 reference

Europe PubMed Central

2 September 2017

Susan P Lees-Miller

3

1 reference

Europe PubMed Central

2 September 2017

language of work or name

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publication date

14 October 2004

1 reference

Europe PubMed Central

2 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

2 September 2017

279

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Europe PubMed Central

2 September 2017

53272-53281

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Europe PubMed Central

2 September 2017

51

1 reference

Europe PubMed Central

2 September 2017

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Stress signals utilize multiple pathways to stabilize p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Multisite phosphorylation provides sophisticated regulation of transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

The genetic defect in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Oxidative stress in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Cancer risk and the ATM gene: a continuing debate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

ATM heterozygote cells exhibit intermediate levels of apoptosis in response to streptonigrin and etoposide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406879200

21 January 2018

Identifiers

10.1074/JBC.M406879200

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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