(Q38349388)

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Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.

scientific article published on 09 October 2003

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scholarly article

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Europe PubMed Central

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19 December 2019

Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14551190%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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19 December 2019

4

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19 December 2019

Yehuda G Assaraf

5

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19 December 2019

author name string

Lilah Rothem

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19 December 2019

Yotam Kaufman

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19 December 2019

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9 October 2003

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19 December 2019

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11

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Journal of Biological Chemistry

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19 December 2019

279

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19 December 2019

1

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19 December 2019

374-384

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19 December 2019

Membrane transport of folates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Sequence-specific interactions of nuclear factors with the insulin gene enhancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Effects of DNA methylation on DNA-binding proteins and gene expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Identification and characterization of a family of mammalian methyl-CpG binding proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Active repression of methylated genes by the chromosomal protein MBD1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Methylation-induced repression--belts, braces, and chromatin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Regulation of the activity of Sp1-related transcription factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Differential expression of the adipocyte amino acid transporter is transactivated by SP1 and SP3 during the 3T3-L1 preadipocyte differentiation process

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Transcription factor Sp3 is regulated by acetylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Killing the messenger: new insights into nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

The role of impaired transport in (pre)clinical resistance to methotrexate: insights on new antifolates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

CpG methylation remodels chromatin structure in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309092200

21 January 2018

Identifiers

10.1074/JBC.M309092200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14551190%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14551190%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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