(Q35173884)

6 August 2017

1 reference

title

Membrane transport of folates (English)

1 reference

6 August 2017

Larry H Matherly

1

1 reference

PubMed ID

12852262

6 August 2017

David I Goldman

series ordinal

2

1 reference

6 August 2017

1 January 2003

1 reference

6 August 2017

Vitamins and Hormones

1 reference

6 August 2017

66

1 reference

6 August 2017

403-456

1 reference

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

1 reference

7 January 2021

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mammalian ABC transporters in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Organization of the murine reduced folate carrier gene and identification of variant splice forms

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Chromosomal localization of the reduced folate transporter gene (SLC19A1) in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

RFC-1 gene expression regulates folate absorption in mouse small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The human ATP-binding cassette (ABC) transporter superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Polymorphisms in genes involved in folate metabolism as risk factors for NTDs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: further evidence for separate influx and efflux systems with different energetic requirements

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Repression of human reduced folate carrier gene expression by wild type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Cloning of the human thiamine transporter, a member of the folate transporter family

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The inhibitory effect of the 5' untranslated region of muscle acylphosphatase mRNA on protein expression is relieved during cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A mutation in the 5' untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The effect of rifampin treatment on intestinal expression of human MRP transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Further studies on the charge-related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome-cell association

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Alterations of the carrier-mediated transport of an anionic solute, methotrexate, by charged liposomes in Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

K+-induced alterations of energetics and exchange diffusion in the carrier-mediated transport of the folic acid analog, methotrexate, in Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A model system for the study of heteroexchange diffusion: Methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The characteristics of the membrane transport of amethopterin and the naturally occurring folates

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1).

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

On the nature of permeability of sarcoma-180 cells to amethopterin in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transport of methotrexate in L1210 cells: effect of ions on the rate and extent of uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Anion exchange mechanism for transport of methotrexate in L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structural requirements for anion substrates of the methotrexate transport system in L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Inhibitory effects of probenecid on the individual transport routes which mediate the influx and efflux of methotrexate in L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Na+ and pH dependence of 5-methyltetrahydrofolic acid and methotrexate transport in freshly isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transport of folates and antifolates in liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transport of methotrexate in basolateral membrane vesicles from rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transport of methotrexate into PC-3 human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A functional, active transport system for methotrexate in freshly isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

5-Methyltetrahydrofolate transport in basolateral membrane vesicles from human liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Altered folate-binding protein mRNA stability in KB cells grown in folate-deficient medium

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Regulation of folate-binding protein gene expression by DNA methylation in methotrexate-resistant KB cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The pharmacology and clinical use of methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Post-transcriptional regulation of rat CYP2E1 expression: role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

MRP3, an organic anion transporter able to transport anti-cancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Folate-mediated targeting: from diagnostics to drug and gene delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Complete mapping of divergent amino acids responsible for differential ligand binding of folate receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Potocytosis. Robert Feulgen Lecture.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

1 reference

7 January 2021

Structural organization of the reduced folate carrier gene in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Human intestinal folate transport: cloning, expression, and distribution of complementary RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Strategy for the treatment of acute myelogenous leukemia based on folate receptor beta-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Molecular cloning of the human placental folate transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Genomic organization of the human folate receptor genes on chromosome 11q13

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

SLC19A3 encodes a second thiamine transporter ThTr2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Endocytosis of GPI-linked membrane folate receptor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Tissue-specific promoters of the alpha human folate receptor gene yield transcripts with divergent 5' leader sequences and different translational efficiencies

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Chromosomal localization of the murine RFC-1 gene encoding a folate transporter and its amplification in an antifolate resistant variant overproducing the transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Molecular aspects of renal anionic drug transport

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutations in the reduced-folate carrier affect protein localization and stability

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Functional role of arginine 373 in substrate translocation by the reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Studies on the intestinal surface acid microclimate: developmental aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Intracellular regulation of intestinal folate uptake: studies with cultured IEC-6 epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structural and functional analysis of the human KB cell folate receptor gene P4 promoter: cooperation of three clustered Sp1-binding sites with initiator region for basal promoter activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Tissue distribution and induction of human multidrug resistant protein 3

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Interaction of folylpolyglutamates with enzymes in one-carbon metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The cotransport systems

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Isolation of a family of organic anion transporters from human liver and kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Biological and clinical implications of the MTHFR C677T polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Molecular cloning of a gene involved in methotrexate uptake by DNA-mediated gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structure and regulation of a polymorphic gene encoding folate receptor type gamma/gamma'.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structural organization of the human reduced folate carrier gene: evidence for 5' heterogeneity in lymphoblast mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Clustering of GPI-anchored folate receptor independent of both cross-linking and association with caveolin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Structure and organization of the human reduced folate carrier gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2803%2901012-4

7 January 2021

10.1016/S0083-6729(03)01012-4

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12852262