(Q38366276)

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Photosensitizing Activity of Endogenous Eye Lens Chromophores: An Attempt to Unravel Their Contributions to Photo-Aging and Cataract Disease

scientific article published on 28 March 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 September 2017

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Europe PubMed Central

Photosensitizing Activity of Endogenous Eye Lens Chromophores: An Attempt to Unravel Their Contributions to Photo-Aging and Cataract Disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Bertrand Friguet

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Felipe Avila

1

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Eduardo Silva

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

28 March 2015

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Photochemistry and Photobiology

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

91

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

767-779

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

On the growth and internal structure of the human lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Age-dependent deamidation of lifelong proteins in the human lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Ageing and vision: structure, stability and function of lens crystallins

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Age-related nuclear cataract-oxidation is the key.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Age-dependent protein modifications and declining proteasome activity in the human lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Similarity of the yellow chromophores isolated from human cataracts with those from ascorbic acid-modified calf lens proteins: evidence for ascorbic acid glycation during cataract formation

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Lens retrodots and vacuoles and their associations with the prevalence and incidence of age-related cataract

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

The assessment of lens opacities in clinical practice: results of a national survey

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Blindness due to cataract: epidemiology and prevention

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

The prevalence of age-related eye diseases and visual impairment in aging: current estimates

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Prevalence of visual impairment and blindness in Upper Egypt: a gender-based perspective

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Cataract prevalence and prevention in Europe: a literature review

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Genetic and environmental underpinnings to age-related ocular diseases

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Dietary carbohydrate in relation to cortical and nuclear lens opacities in the melbourne visual impairment project

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

In vivo studies on the effect of UV-radiation on the eye lens in animals

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Ultraviolet light exposure and lens opacities: the Beaver Dam Eye Study

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

The differential effect of ultraviolet light exposure on cataract rate across regions of the lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Solar ultraviolet radiation and skin cancer

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photooxidation of lens proteins with xanthurenic acid: a putative chromophore for cataractogenesis

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Role of xanthurenic acid 8-O-beta-D-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photodynamics of cataract: an update on endogenous chromophores and antioxidants

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Tryptophan metabolites from young human lenses and the photooxidation of ascorbic acid by UVA light

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Oxindolealanine in age-related human cataracts

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Optical effects of exposing intact human lenses to ultraviolet radiation and visible light

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Age-related changes in the kinetics of water transport in normal human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

2-ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine) is a newly identified advanced glycation end product in cataractous and aged human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Advanced glycation end products in senile diabetic and nondiabetic patients with cataract

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Accumulation of the hydroxyl free radical markers meta-, ortho-tyrosine and DOPA in cataractous lenses is accompanied by a lower protein and phenylalanine content of the water-soluble phase.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

An increase in phosphorylation and truncation of crystallin with the progression of cataracts

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Autosensitized oxidation of glycated bovine lens proteins irradiated with UVA-visible light at low oxygen concentration

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Simultaneous chemical and photochemical protein crosslinking induced by irradiation of eye lens proteins in the presence of ascorbate: the photosensitizing role of an UVA-visible-absorbing decomposition product of vitamin C.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photochemical properties of UV Filter molecules of the human eye.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Assay of fluorescent glucosides in the human lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Biochemical properties of indoleamine 2,3-dioxygenase: from structure to optimized design of inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Oxygen distribution in the human eye: relevance to the etiology of open-angle glaucoma after vitrectomy

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Role of aromatic amino acid tryptophan UVA-photoproducts in the determination of drug photosensitization mechanism: a comparison between methylene blue and naproxen

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Tryptophan oxidation by singlet molecular oxygen [O2(1Deltag)]: mechanistic studies using 18O-labeled hydroperoxides, mass spectrometry, and light emission measurements

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identification of oxidation products and free radicals of tryptophan by mass spectrometry

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Comment on 'The photosensitiser xanthurenic acid is not present in normal human lenses' by P.G. Hains et al. [Exp. Eye Res. 77 (2003) 547-553].

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

The photosensitiser xanthurenic acid is not present in normal human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Presence and distribution of L-kynurenine aminotransferases immunoreactivity in human cataractous lenses.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identification of a novel fluorophore, xanthurenic acid 8- O -beta-D-glucoside in human brunescent cataract

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Kinetics and mechanism of thermal decomposition of kynurenines and biomolecular conjugates: ramifications for the modification of mammalian eye lens proteins

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Protein-bound kynurenine is a photosensitizer of oxidative damage

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Role of complex formation in the photosensitized degradation of DNA induced by N'-formylkynurenine

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photosensitizing properties of N-formylkynurenine

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Kynurenine-induced photo oxidative damage to lens in vitro: protective effect of caffeine

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

A compilation of singlet oxygen yields from biologically relevant molecules

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photoactivity of kynurenine-derived UV filters.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Age-related nuclear cataract: a lens transport problem

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Protein-bound kynurenine decreases with the progression of age-related nuclear cataract

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Ultrafast excited-state dynamics of kynurenine, a UV filter of the human eye.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Photo-oxidation of proteins and its role in cataractogenesis.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Studies on singlet oxygen formation and UVA light-mediated photobleaching of the yellow chromophores in human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Lens UVA photobiology

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Conversion of arginine into ornithine by advanced glycation in senescent human collagen and lens crystallins

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Rate of formation of AGEs during ascorbate glycation and during aging in human lens tissue

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Diabetic cataract formation: potential role of glycosylation of lens crystallins

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Degradation of glucose: reinvestigation of reactive alpha-Dicarbonyl compounds

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Sugars including erythronic and threonic acids in human aqueous humour

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Vitamin C degradation products and pathways in the human lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Counterpoint: The lens fluid circulation model--a critical appraisal

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Advanced glycation endproducts as UVA photosensitizers of tryptophan and ascorbic acid: consequences for the lens

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Short wavelength light filtering by the natural human lens and IOLs -- implications for entrainment of circadian rhythm.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Violet and blue light blocking intraocular lenses: photoprotection versus photoreception

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Impact of cataract surgery on sleep in patients receiving either ultraviolet-blocking or blue-filtering intraocular lens implants

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identification of 3,4-dihydroxy-2-oxo-butanal (L-threosone) as an intermediate compound in oxidative degradation of dehydro-L-ascorbic acid and 2,3-diketo-L-gulonic acid in a deuterium oxide phosphate buffer

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Analysis of the transformation products of dehydro-L-ascorbic acid by ion-pairing high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Advanced glycation endproducts induce photocrosslinking and oxidation of bovine lens proteins through type-I mechanism

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Is the lens canned?

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Characterization of key chromophores formed by nonenzymatic browning of hexoses and L-alanine by using the color activity concept

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Formation of furan and methylfuran by maillard-type reactions in model systems and food

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Novel protein modification by kynurenine in human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Human lens coloration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenine O-beta-D-glucoside.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis.

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Structure elucidation of a novel yellow chromophore from human lens protein

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

LC-MS display of the total modified amino acids in cataract lens proteins and in lens proteins glycated by ascorbic acid in vitro

1 reference

https://api.crossref.org/works/10.1111%2FPHP.12443

21 January 2018

Identifiers

10.1111/PHP.12443

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25726851%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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