(Q38367657)

2 September 2017

1 reference

title

Targeting Na⁺/K⁺ -translocating adenosine triphosphatase in cancer treatment (English)

1 reference

2 September 2017

Cameron T Durlacher

1

1 reference

2 September 2017

Kevin Chow

2

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2 September 2017

Xiao-Wu Chen

3

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2 September 2017

Zhi-Xu He

4

1 reference

2 September 2017

Xueji Zhang

5

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2 September 2017

Tianxin Yang

6

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2 September 2017

Shu-Feng Zhou

7

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2 September 2017

publication date

1 May 2015

1 reference

Clinical and Experimental Pharmacology and Physiology

2 September 2017

published in

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2 September 2017

volume

42

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2 September 2017

issue

5

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2 September 2017

page(s)

427-443

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Structure and mechanism of ATP-dependent phospholipid transporters

2 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Plasma membrane calcium ATPases and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

From Na+/K+-ATPase and cardiac glycosides to cytotoxicity and cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Novel therapeutic applications of cardiac glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of the sodium–potassium pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of the sodium-potassium pump at 2.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Biochemistry of Na,K-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Na,K-ATPase alpha4 isoform is essential for sperm fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Molecular mechanisms of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Ouabain-induced alterations of the apical junctional complex involve α1 and β1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Roles for microRNAs in conferring robustness to biological processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

MicroRNAs contribute to the maintenance of cell-type-specific physiological characteristics: miR-192 targets Na+/K+-ATPase β1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Signal integration by JNK and p38 MAPK pathways in cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

New roles for Src kinases in control of cell survival and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Src kinase integrates PI3K/Akt and MAPK/ERK1/2 pathways in T3-induced Na-K-ATPase activity in adult rat alveolar cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment of bladder cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cell signaling associated with Na(+)/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA/Akt by ouabain is independent of Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Regulation of intracellular cholesterol distribution by Na/K-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Regulation of alpha1 Na/K-ATPase expression by cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Lipids: Cholesterol metabolite unmasked as a key player in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

New insights into the regulation of Na+,K+-ATPase by ouabain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycosides exert anticancer effects by inducing immunogenic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Role of mitochondrial dysfunction in cardiac glycoside toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Autophagy as a regulated pathway of cellular degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Atomistic autophagy: the structures of cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Autophagy: renovation of cells and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiotonic steroids-mediated Na+/K+-ATPase targeting could circumvent various chemoresistance pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycosides decrease prostate specific antigen expression by down-regulation of prostate derived Ets factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Voltage-dependent K+ channels as oncotargets in malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

FXYD3 expression in gliomas and its clinicopathological significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digoxin use and the risk of cancers of the corpus uteri, ovary and cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Molecular pathways: digoxin use and estrogen-sensitive cancers--risks and possible therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digoxin use and risk of invasive breast cancer: evidence from the Nurses' Health Study and meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Breast cancer in women using digoxin: tumor characteristics and relapse risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Signal pathways in ouabain-induced proliferation of leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Targeting poly (ADP-ribose) polymerase partially contributes to bufalin-induced cell death in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digoxin downregulates NDRG1 and VEGF through the inhibition of HIF-1α under hypoxic conditions in human lung adenocarcinoma A549 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

PBI-05204, a supercritical CO₂ extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Anoikis molecular pathways and its role in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Changes in sodium pump expression dictate the effects of ouabain on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

HIF-1alpha and calcium signaling as targets for treatment of prostate cancer by cardiac glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Efficacy and safety of Huachansu combined with chemotherapy in advanced gastric cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Analysis of the Na,K-ATPase α- and β-subunit expression profiles of bladder cancer using tissue microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2F1440-1681.12385

21 January 2018

Identifiers

DOI

10.1111/1440-1681.12385

1 reference

release_cyyhngn5cvb45m5gyyfttwadcu

2 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cyyhngn5cvb45m5gyyfttwadcu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference